FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068645723> ?p ?o ?g. }

• W2068645723 endingPage "68" @default.
• W2068645723 startingPage "1259" @default.
• W2068645723 abstract "Triptolide, a diterpene triepoxide isolated from the traditional Chinese medicinal vine Trypterygium wilfordii hook f., has been shown to induce rapid apoptosis in a myriad of cancer cell lines and inhibit NFkappaB transactivation. To understand further the general cellular mechanisms for this therapeutically relevant natural product, binding and biological activities were assessed. Studies showed that triptolide binding was saturable, reversible, and primarily localized to cell membranes. Depletion of calcium enhanced overall binding while differentially modulating biological function. Furthermore, triptolide's structural moieties demonstrated variability in the regulation of cell death versus inhibition of NFkappaB transactivation. These results implicate triptolide in the manipulation of at least two distinct cellular pathways with differing requirements for calcium and effective triptolide concentration in order to elicit each particular biological function." @default.
• W2068645723 created "2016-06-24" @default.
• W2068645723 creator A5016866989 @default.
• W2068645723 creator A5063241230 @default.
• W2068645723 date "2005-12-01" @default.
• W2068645723 modified "2023-10-16" @default.
• W2068645723 title "Studies on calcium dependence reveal multiple modes of action for triptolide." @default.
• W2068645723 cites W1607531254 @default.
• W2068645723 cites W1650401181 @default.
• W2068645723 cites W1942667155 @default.
• W2068645723 cites W1969791237 @default.
• W2068645723 cites W1969876249 @default.
• W2068645723 cites W1983799279 @default.
• W2068645723 cites W1986643690 @default.
• W2068645723 cites W1991576282 @default.
• W2068645723 cites W1994342907 @default.
• W2068645723 cites W2012369036 @default.
• W2068645723 cites W2014106380 @default.
• W2068645723 cites W2015426350 @default.
• W2068645723 cites W2036145275 @default.
• W2068645723 cites W2039809463 @default.
• W2068645723 cites W2057333190 @default.
• W2068645723 cites W2061836260 @default.
• W2068645723 cites W2081443693 @default.
• W2068645723 cites W2084570982 @default.
• W2068645723 cites W2098859322 @default.
• W2068645723 cites W2107948773 @default.
• W2068645723 cites W2116048534 @default.
• W2068645723 cites W2134189872 @default.
• W2068645723 cites W2138298723 @default.
• W2068645723 cites W2158198954 @default.
• W2068645723 cites W2163166029 @default.
• W2068645723 cites W2337955099 @default.
• W2068645723 cites W2374838287 @default.
• W2068645723 cites W2396705696 @default.
• W2068645723 cites W2402878720 @default.
• W2068645723 cites W2417146944 @default.
• W2068645723 cites W2418105846 @default.
• W2068645723 cites W4249759827 @default.
• W2068645723 cites W56747938 @default.
• W2068645723 doi "https://doi.org/10.1016/j.chembiol.2005.09.009" @default.
• W2068645723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2486259" @default.
• W2068645723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16356843" @default.
• W2068645723 hasPublicationYear "2005" @default.
• W2068645723 type Work @default.
• W2068645723 sameAs 2068645723 @default.
• W2068645723 citedByCount "41" @default.
• W2068645723 countsByYear W20686457232012 @default.
• W2068645723 countsByYear W20686457232013 @default.
• W2068645723 countsByYear W20686457232014 @default.
• W2068645723 countsByYear W20686457232015 @default.
• W2068645723 countsByYear W20686457232017 @default.
• W2068645723 countsByYear W20686457232018 @default.
• W2068645723 countsByYear W20686457232019 @default.
• W2068645723 countsByYear W20686457232021 @default.
• W2068645723 countsByYear W20686457232022 @default.
• W2068645723 crossrefType "journal-article" @default.
• W2068645723 hasAuthorship W2068645723A5016866989 @default.
• W2068645723 hasAuthorship W2068645723A5063241230 @default.
• W2068645723 hasBestOaLocation W20686457231 @default.
• W2068645723 hasConcept C104317684 @default.
• W2068645723 hasConcept C116073593 @default.
• W2068645723 hasConcept C1292079 @default.
• W2068645723 hasConcept C1491633281 @default.
• W2068645723 hasConcept C178790620 @default.
• W2068645723 hasConcept C185592680 @default.
• W2068645723 hasConcept C190283241 @default.
• W2068645723 hasConcept C202751555 @default.
• W2068645723 hasConcept C2776120743 @default.
• W2068645723 hasConcept C2779396153 @default.
• W2068645723 hasConcept C2781164371 @default.
• W2068645723 hasConcept C31573885 @default.
• W2068645723 hasConcept C519063684 @default.
• W2068645723 hasConcept C54355233 @default.
• W2068645723 hasConcept C55493867 @default.
• W2068645723 hasConcept C62112901 @default.
• W2068645723 hasConcept C81885089 @default.
• W2068645723 hasConcept C86339819 @default.
• W2068645723 hasConcept C86803240 @default.
• W2068645723 hasConcept C95444343 @default.
• W2068645723 hasConceptScore W2068645723C104317684 @default.
• W2068645723 hasConceptScore W2068645723C116073593 @default.
• W2068645723 hasConceptScore W2068645723C1292079 @default.
• W2068645723 hasConceptScore W2068645723C1491633281 @default.
• W2068645723 hasConceptScore W2068645723C178790620 @default.
• W2068645723 hasConceptScore W2068645723C185592680 @default.
• W2068645723 hasConceptScore W2068645723C190283241 @default.
• W2068645723 hasConceptScore W2068645723C202751555 @default.
• W2068645723 hasConceptScore W2068645723C2776120743 @default.
• W2068645723 hasConceptScore W2068645723C2779396153 @default.
• W2068645723 hasConceptScore W2068645723C2781164371 @default.
• W2068645723 hasConceptScore W2068645723C31573885 @default.
• W2068645723 hasConceptScore W2068645723C519063684 @default.
• W2068645723 hasConceptScore W2068645723C54355233 @default.
• W2068645723 hasConceptScore W2068645723C55493867 @default.
• W2068645723 hasConceptScore W2068645723C62112901 @default.
• W2068645723 hasConceptScore W2068645723C81885089 @default.
• W2068645723 hasConceptScore W2068645723C86339819 @default.

• next