Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068647772> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2068647772 endingPage "69" @default.
- W2068647772 startingPage "63" @default.
- W2068647772 abstract "BACKGROUND Curettage and electrodesiccation (C&D) is a widely used method to treat nodular basal cell carcinoma (BCC). However, residual tumor is present immediately after the procedure in approximately 20 to 40% of cases. Imiquimod, a topical immune response modifier that targets Toll-like receptor 7, is currently approved for superficial BCC. OBJECTIVE In a double-blind, vehicle-controlled study, the administration of imiquimod after C&D was investigated to determine if the combination regimen would reduce the frequency of residual tumor compared with C&D alone in patients with nodular BCC. METHODS Twenty patients received three cycles of C&D followed by imiquimod 5% or vehicle cream once daily for 1 month as adjunctive therapy. The primary end point was the frequency of residual tumor. The secondary end points included the time to heal and cosmetic appearance. RESULTS Twenty patients were randomized to imiquimod (n=10) or vehicle (n=10) treatment group. At 8 weeks, the proportion of patients with residual tumor was substantially decreased with imiquimod therapy (10%) compared with vehicle (40%). Wounds in the vehicle group healed more quickly than those in the imiquimod group, although by 8 weeks, all excision sites were healed. The majority of scars in the control group were atrophic and hypopigmented, whereas most scars in the imiquimod group were at and slightly pink. CONCLUSION Imiquimod 5% cream once daily for 1 month as adjunctive therapy after C&D substantially reduced the frequency of residual tumor and improved the cosmetic appearance compared with C&D alone. These preliminary results suggest that further studies to investigate imiquimod adjunctive therapy are warranted." @default.
- W2068647772 created "2016-06-24" @default.
- W2068647772 creator A5027499850 @default.
- W2068647772 date "2008-06-28" @default.
- W2068647772 modified "2023-10-17" @default.
- W2068647772 title "Pilot Study of Imiquimod 5% Cream as Adjunctive Therapy to Curettage and Electrodesiccation for Nodular Basal Cell Carcinoma" @default.
- W2068647772 cites W1989021197 @default.
- W2068647772 cites W2005215006 @default.
- W2068647772 cites W2008893599 @default.
- W2068647772 cites W2022842160 @default.
- W2068647772 cites W2053682826 @default.
- W2068647772 cites W2063463674 @default.
- W2068647772 cites W2077908073 @default.
- W2068647772 cites W2080555083 @default.
- W2068647772 cites W2098231073 @default.
- W2068647772 cites W2129147888 @default.
- W2068647772 cites W4243616336 @default.
- W2068647772 doi "https://doi.org/10.1111/1524-4725.2006.32007" @default.
- W2068647772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16393600" @default.
- W2068647772 hasPublicationYear "2008" @default.
- W2068647772 type Work @default.
- W2068647772 sameAs 2068647772 @default.
- W2068647772 citedByCount "20" @default.
- W2068647772 countsByYear W20686477722012 @default.
- W2068647772 countsByYear W20686477722014 @default.
- W2068647772 countsByYear W20686477722016 @default.
- W2068647772 countsByYear W20686477722020 @default.
- W2068647772 countsByYear W20686477722021 @default.
- W2068647772 countsByYear W20686477722023 @default.
- W2068647772 crossrefType "journal-article" @default.
- W2068647772 hasAuthorship W2068647772A5027499850 @default.
- W2068647772 hasConcept C126322002 @default.
- W2068647772 hasConcept C141071460 @default.
- W2068647772 hasConcept C16005928 @default.
- W2068647772 hasConcept C2777642821 @default.
- W2068647772 hasConcept C2777750650 @default.
- W2068647772 hasConcept C2778804307 @default.
- W2068647772 hasConcept C2778842199 @default.
- W2068647772 hasConcept C2779112978 @default.
- W2068647772 hasConcept C2779904257 @default.
- W2068647772 hasConcept C3018162438 @default.
- W2068647772 hasConcept C3019992690 @default.
- W2068647772 hasConcept C71924100 @default.
- W2068647772 hasConceptScore W2068647772C126322002 @default.
- W2068647772 hasConceptScore W2068647772C141071460 @default.
- W2068647772 hasConceptScore W2068647772C16005928 @default.
- W2068647772 hasConceptScore W2068647772C2777642821 @default.
- W2068647772 hasConceptScore W2068647772C2777750650 @default.
- W2068647772 hasConceptScore W2068647772C2778804307 @default.
- W2068647772 hasConceptScore W2068647772C2778842199 @default.
- W2068647772 hasConceptScore W2068647772C2779112978 @default.
- W2068647772 hasConceptScore W2068647772C2779904257 @default.
- W2068647772 hasConceptScore W2068647772C3018162438 @default.
- W2068647772 hasConceptScore W2068647772C3019992690 @default.
- W2068647772 hasConceptScore W2068647772C71924100 @default.
- W2068647772 hasIssue "1" @default.
- W2068647772 hasLocation W20686477721 @default.
- W2068647772 hasLocation W20686477722 @default.
- W2068647772 hasOpenAccess W2068647772 @default.
- W2068647772 hasPrimaryLocation W20686477721 @default.
- W2068647772 hasRelatedWork W127584262 @default.
- W2068647772 hasRelatedWork W181910591 @default.
- W2068647772 hasRelatedWork W2005111710 @default.
- W2068647772 hasRelatedWork W2012603298 @default.
- W2068647772 hasRelatedWork W2058842191 @default.
- W2068647772 hasRelatedWork W2121668765 @default.
- W2068647772 hasRelatedWork W2408772766 @default.
- W2068647772 hasRelatedWork W2800672657 @default.
- W2068647772 hasRelatedWork W4249586998 @default.
- W2068647772 hasRelatedWork W5922124 @default.
- W2068647772 hasVolume "32" @default.
- W2068647772 isParatext "false" @default.
- W2068647772 isRetracted "false" @default.
- W2068647772 magId "2068647772" @default.
- W2068647772 workType "article" @default.