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- W2068650334 abstract "Abstract So far, with human influenza A viruses, only hemagglutinin (HA) subtypes 1, 2, or 3 were found. For pandemic planning, the question, whether other HA subtypes are compatible to create new human pandemic strains by reassortment, arises. Therefore, we crossed an amantadine-resistant variant of the human A/Singapore/57 (Sing) strain (H2N2) with various avian strains of different HA subtypes in the presence of amantadine and of anti-H2-antibodies. With A/Duck/Ukraine/63 (H3N8) and some other avian strains isolated recently in Hong Kong, large plaque-forming reassortants with the Sing-M-gene and the avian HA could be obtained in high yields, while with A/Chicken/Germany N/49 (Virus N) (H10N7) and some other avian strains, the yields were extremely low, and the remaining plaques were very small, and partly turbid and fuzzy. These observations may indicate that certain avian HA subtypes are not compatible to replace the HA-gene of the present human influenza A viruses to create a viable pandemic strain." @default.
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- W2068650334 date "2001-10-01" @default.
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- W2068650334 title "Compatibility of various avian HA subtypes with the genome of human influenza A viruses" @default.
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- W2068650334 doi "https://doi.org/10.1016/s0531-5131(01)00669-0" @default.
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