FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068654319> ?p ?o ?g. }

• W2068654319 endingPage "5860" @default.
• W2068654319 startingPage "5855" @default.
• W2068654319 abstract "A new series of ketoprofen analogs were synthesized to evaluate their biological activities as selective cyclooxygenase-2 (COX-2) inhibitors. In vitro COX-1 and COX-2 inhibition studies showed that all compounds were potent and selective inhibitors of the COX-2 isozyme with IC50 values in the highly potent 0.057–0.085 μM range, and COX-2 selectivity indexes in the 115 to >1298.7 range. Compounds possessing azido pharmacophore group (8a and 8b) exhibited highly COX-2 inhibitory selectivity and potency even more than reference drug celecoxib. Molecular modeling studies indicated that the azido substituent can be inserted deeply into the secondary pocket of COX-2 active site for interactions with Arg513." @default.
• W2068654319 created "2016-06-24" @default.
• W2068654319 creator A5021252008 @default.
• W2068654319 creator A5075132123 @default.
• W2068654319 date "2010-08-01" @default.
• W2068654319 modified "2023-10-18" @default.
• W2068654319 title "Design, synthesis, and biological evaluation of ketoprofen analogs as potent cyclooxygenase-2 inhibitors" @default.
• W2068654319 cites W1711251896 @default.
• W2068654319 cites W1967257081 @default.
• W2068654319 cites W1976491124 @default.
• W2068654319 cites W1987613645 @default.
• W2068654319 cites W2016361268 @default.
• W2068654319 cites W2018651435 @default.
• W2068654319 cites W2023200971 @default.
• W2068654319 cites W2024009660 @default.
• W2068654319 cites W2024534943 @default.
• W2068654319 cites W2030850720 @default.
• W2068654319 cites W2051686420 @default.
• W2068654319 cites W2055114921 @default.
• W2068654319 cites W2055838920 @default.
• W2068654319 cites W2070609164 @default.
• W2068654319 cites W2072769526 @default.
• W2068654319 cites W2075554206 @default.
• W2068654319 cites W2083375837 @default.
• W2068654319 cites W2086735062 @default.
• W2068654319 cites W2120112134 @default.
• W2068654319 cites W2158534713 @default.
• W2068654319 doi "https://doi.org/10.1016/j.bmc.2010.06.094" @default.
• W2068654319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20650641" @default.
• W2068654319 hasPublicationYear "2010" @default.
• W2068654319 type Work @default.
• W2068654319 sameAs 2068654319 @default.
• W2068654319 citedByCount "53" @default.
• W2068654319 countsByYear W20686543192012 @default.
• W2068654319 countsByYear W20686543192013 @default.
• W2068654319 countsByYear W20686543192014 @default.
• W2068654319 countsByYear W20686543192016 @default.
• W2068654319 countsByYear W20686543192017 @default.
• W2068654319 countsByYear W20686543192018 @default.
• W2068654319 countsByYear W20686543192019 @default.
• W2068654319 countsByYear W20686543192020 @default.
• W2068654319 countsByYear W20686543192021 @default.
• W2068654319 countsByYear W20686543192022 @default.
• W2068654319 countsByYear W20686543192023 @default.
• W2068654319 crossrefType "journal-article" @default.
• W2068654319 hasAuthorship W2068654319A5021252008 @default.
• W2068654319 hasAuthorship W2068654319A5075132123 @default.
• W2068654319 hasConcept C114373084 @default.
• W2068654319 hasConcept C116073593 @default.
• W2068654319 hasConcept C118792377 @default.
• W2068654319 hasConcept C119795356 @default.
• W2068654319 hasConcept C161790260 @default.
• W2068654319 hasConcept C181199279 @default.
• W2068654319 hasConcept C185592680 @default.
• W2068654319 hasConcept C193042331 @default.
• W2068654319 hasConcept C202751555 @default.
• W2068654319 hasConcept C2776467144 @default.
• W2068654319 hasConcept C2776980637 @default.
• W2068654319 hasConcept C2778689049 @default.
• W2068654319 hasConcept C2779689624 @default.
• W2068654319 hasConcept C2779751750 @default.
• W2068654319 hasConcept C2780744026 @default.
• W2068654319 hasConcept C43617362 @default.
• W2068654319 hasConcept C55493867 @default.
• W2068654319 hasConcept C56173144 @default.
• W2068654319 hasConcept C57992300 @default.
• W2068654319 hasConcept C71240020 @default.
• W2068654319 hasConcept C71924100 @default.
• W2068654319 hasConcept C98274493 @default.
• W2068654319 hasConceptScore W2068654319C114373084 @default.
• W2068654319 hasConceptScore W2068654319C116073593 @default.
• W2068654319 hasConceptScore W2068654319C118792377 @default.
• W2068654319 hasConceptScore W2068654319C119795356 @default.
• W2068654319 hasConceptScore W2068654319C161790260 @default.
• W2068654319 hasConceptScore W2068654319C181199279 @default.
• W2068654319 hasConceptScore W2068654319C185592680 @default.
• W2068654319 hasConceptScore W2068654319C193042331 @default.
• W2068654319 hasConceptScore W2068654319C202751555 @default.
• W2068654319 hasConceptScore W2068654319C2776467144 @default.
• W2068654319 hasConceptScore W2068654319C2776980637 @default.
• W2068654319 hasConceptScore W2068654319C2778689049 @default.
• W2068654319 hasConceptScore W2068654319C2779689624 @default.
• W2068654319 hasConceptScore W2068654319C2779751750 @default.
• W2068654319 hasConceptScore W2068654319C2780744026 @default.
• W2068654319 hasConceptScore W2068654319C43617362 @default.
• W2068654319 hasConceptScore W2068654319C55493867 @default.
• W2068654319 hasConceptScore W2068654319C56173144 @default.
• W2068654319 hasConceptScore W2068654319C57992300 @default.
• W2068654319 hasConceptScore W2068654319C71240020 @default.
• W2068654319 hasConceptScore W2068654319C71924100 @default.
• W2068654319 hasConceptScore W2068654319C98274493 @default.
• W2068654319 hasIssue "16" @default.
• W2068654319 hasLocation W20686543191 @default.
• W2068654319 hasLocation W20686543192 @default.
• W2068654319 hasOpenAccess W2068654319 @default.
• W2068654319 hasPrimaryLocation W20686543191 @default.
• W2068654319 hasRelatedWork W1977674950 @default.
• W2068654319 hasRelatedWork W1988600167 @default.

• next