FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068657595> ?p ?o ?g. }

• W2068657595 endingPage "114" @default.
• W2068657595 startingPage "106" @default.
• W2068657595 abstract "Chronic stress is known to modulate cannabinoid CB1 receptor binding densities in corticolimbic structures, in a region-dependent manner; however, the ontogeny of these changes and the degree to which they recover following exposure to stress have yet to be determined. To this extent, we examined both the immediate and sustained effects (following a 40-day recovery period) of a repeated restraint stress paradigm (30-min restraint/day for 10 days) on CB1 receptor binding in the prefrontal cortex (PFC), hippocampus and amygdala in both adolescent (stress onset at post-natal day [PND] 35) and adult (stress onset at PND 75) male Sprague-Dawley rats. Consistent with previous reports, we found that repeated stress in adult rats resulted in an increase in CB1 receptor binding in the PFC, a reduction in CB1 receptor binding in the hippocampus and no effect in the amygdala. Interestingly, adolescent rats exposed to repeated restraint stress did not show any change in hippocampal CB1 receptor density, but exhibited an upregulation of CB1 receptor binding in both the PFC and amygdala. In adults, a 40-day recovery period resulted in a normalization of CB1 receptor binding in the PFC, and surprisingly a pronounced upregulation of CB1 receptor binding in the hippocampus, possibly indicative of a rebound effect. Adolescents similarly exhibited this rebound increase in hippocampal CB1 receptor binding, despite a lack in immediate downregulation following repeated restraint. Of particular interest, adolescents exposed to stress were found to have a sustained downregulation of prefrontocortical CB1 receptors in adulthood, which may relate to some of the reported sustained behavioral effects of stress in adolescence. Collectively, these data indicate that the effects of chronic stress on cannabinoid CB1 receptor binding are modulated by the age of stress exposure and period of recovery following the cessation of stress." @default.
• W2068657595 created "2016-06-24" @default.
• W2068657595 creator A5041457720 @default.
• W2068657595 creator A5065752454 @default.
• W2068657595 date "2013-09-01" @default.
• W2068657595 modified "2023-10-10" @default.
• W2068657595 title "Age of stress exposure modulates the immediate and sustained effects of repeated stress on corticolimbic cannabinoid CB1 receptor binding in male rats" @default.
• W2068657595 cites W1501762129 @default.
• W2068657595 cites W1549089891 @default.
• W2068657595 cites W1898751679 @default.
• W2068657595 cites W1963850092 @default.
• W2068657595 cites W1966656140 @default.
• W2068657595 cites W1969412681 @default.
• W2068657595 cites W1969415886 @default.
• W2068657595 cites W1973653064 @default.
• W2068657595 cites W1975582440 @default.
• W2068657595 cites W1983494600 @default.
• W2068657595 cites W1984959581 @default.
• W2068657595 cites W1985645068 @default.
• W2068657595 cites W1993667526 @default.
• W2068657595 cites W1997302824 @default.
• W2068657595 cites W2000809493 @default.
• W2068657595 cites W2001565222 @default.
• W2068657595 cites W2003823489 @default.
• W2068657595 cites W2009594014 @default.
• W2068657595 cites W2017255572 @default.
• W2068657595 cites W2018750769 @default.
• W2068657595 cites W2020597601 @default.
• W2068657595 cites W2022961682 @default.
• W2068657595 cites W2023110774 @default.
• W2068657595 cites W2023228665 @default.
• W2068657595 cites W2029009210 @default.
• W2068657595 cites W2031111076 @default.
• W2068657595 cites W2031240642 @default.
• W2068657595 cites W2031674889 @default.
• W2068657595 cites W2032997620 @default.
• W2068657595 cites W2033835916 @default.
• W2068657595 cites W2039316705 @default.
• W2068657595 cites W2043545748 @default.
• W2068657595 cites W2045595011 @default.
• W2068657595 cites W2048249572 @default.
• W2068657595 cites W2048308338 @default.
• W2068657595 cites W2050035705 @default.
• W2068657595 cites W2050618347 @default.
• W2068657595 cites W2052569904 @default.
• W2068657595 cites W2054176374 @default.
• W2068657595 cites W2054980594 @default.
• W2068657595 cites W2056795643 @default.
• W2068657595 cites W2057874239 @default.
• W2068657595 cites W2062405004 @default.
• W2068657595 cites W2063359051 @default.
• W2068657595 cites W2063783720 @default.
• W2068657595 cites W2065400194 @default.
• W2068657595 cites W2067214410 @default.
• W2068657595 cites W2067683495 @default.
• W2068657595 cites W2070265214 @default.
• W2068657595 cites W2073174105 @default.
• W2068657595 cites W2073626795 @default.
• W2068657595 cites W2074290211 @default.
• W2068657595 cites W2076385634 @default.
• W2068657595 cites W2076795642 @default.
• W2068657595 cites W2079279567 @default.
• W2068657595 cites W2090774121 @default.
• W2068657595 cites W2093704489 @default.
• W2068657595 cites W2094662319 @default.
• W2068657595 cites W2099390922 @default.
• W2068657595 cites W2100751263 @default.
• W2068657595 cites W2104281927 @default.
• W2068657595 cites W2111259863 @default.
• W2068657595 cites W2111869840 @default.
• W2068657595 cites W2118600442 @default.
• W2068657595 cites W2119202572 @default.
• W2068657595 cites W2120230768 @default.
• W2068657595 cites W2120450264 @default.
• W2068657595 cites W2124037107 @default.
• W2068657595 cites W2124453851 @default.
• W2068657595 cites W2133859389 @default.
• W2068657595 cites W2134689446 @default.
• W2068657595 cites W2138970660 @default.
• W2068657595 cites W2143384095 @default.
• W2068657595 cites W2145152438 @default.
• W2068657595 cites W2150840196 @default.
• W2068657595 cites W2152614652 @default.
• W2068657595 cites W2156333779 @default.
• W2068657595 cites W2157893007 @default.
• W2068657595 cites W2159178030 @default.
• W2068657595 cites W2164216729 @default.
• W2068657595 cites W2167240821 @default.
• W2068657595 cites W2169890964 @default.
• W2068657595 doi "https://doi.org/10.1016/j.neuroscience.2012.11.017" @default.
• W2068657595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23200786" @default.
• W2068657595 hasPublicationYear "2013" @default.
• W2068657595 type Work @default.
• W2068657595 sameAs 2068657595 @default.
• W2068657595 citedByCount "54" @default.
• W2068657595 countsByYear W20686575952013 @default.
• W2068657595 countsByYear W20686575952014 @default.
• W2068657595 countsByYear W20686575952015 @default.

• next