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- W2068662209 abstract "Antidepressants, including the selective serotonin reuptake inhibitors (SSRIs), are thought to exert their clinical effects by enhancing serotonin (5-HT) transmission. However, animal studies show that the full magnitude of this enhancement is reached only following prolonged treatments with SSRIs, consistent with the well-described therapeutic delay of this class of medications. Thus, the clinical efficacy of SSRIs most likely does not emerge from their acute pharmacological actions, but rather indirectly from cellular alterations that develop over the course of a sustained treatment. Here, we show that sustained administration of the SSRI citalopram leads to a homeostatic-like increase in the strength of excitatory glutamate synapses onto 5-HT neurons of the dorsal raphe nucleus that was apparent following one week of treatment. A shorter treatment with citalopram rather induced a paradoxical decrease in the strength of these synapses, which manifested itself by both pre- and postsynaptic mechanisms. As such, these results show that an SSRI treatment induced a concerted and time-dependent modulation of the synaptic drive of 5-HT neurons, which are known to be critically involved in mood regulation. This regulation, and its time course, provide a mechanistic framework that may be relevant not only for explaining the therapeutic delay of antidepressants, but also for the perplexing increases in suicide risks reportedly occurring early in the course of antidepressant treatments." @default.
- W2068662209 created "2016-06-24" @default.
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- W2068662209 date "2015-08-01" @default.
- W2068662209 modified "2023-10-18" @default.
- W2068662209 title "Time-dependent modulation of glutamate synapses onto 5-HT neurons by antidepressant treatment" @default.
- W2068662209 cites W1483876599 @default.
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- W2068662209 cites W1965635592 @default.
- W2068662209 cites W1970498796 @default.
- W2068662209 cites W1973082508 @default.
- W2068662209 cites W1973702950 @default.
- W2068662209 cites W1981097208 @default.
- W2068662209 cites W1984113489 @default.
- W2068662209 cites W1985322212 @default.
- W2068662209 cites W1987083929 @default.
- W2068662209 cites W1988376465 @default.
- W2068662209 cites W1991461979 @default.
- W2068662209 cites W1994702289 @default.
- W2068662209 cites W1998708235 @default.
- W2068662209 cites W2001652592 @default.
- W2068662209 cites W2005520124 @default.
- W2068662209 cites W2006285647 @default.
- W2068662209 cites W2007697968 @default.
- W2068662209 cites W2008826113 @default.
- W2068662209 cites W2010370414 @default.
- W2068662209 cites W2010915373 @default.
- W2068662209 cites W2015701831 @default.
- W2068662209 cites W2019016101 @default.
- W2068662209 cites W2020135601 @default.
- W2068662209 cites W2020542560 @default.
- W2068662209 cites W2032899392 @default.
- W2068662209 cites W2039022088 @default.
- W2068662209 cites W2042556300 @default.
- W2068662209 cites W2043567599 @default.
- W2068662209 cites W2045964630 @default.
- W2068662209 cites W2047535883 @default.
- W2068662209 cites W2048142982 @default.
- W2068662209 cites W2048283236 @default.
- W2068662209 cites W2051531767 @default.
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- W2068662209 cites W2054334939 @default.
- W2068662209 cites W2055526547 @default.
- W2068662209 cites W2065269603 @default.
- W2068662209 cites W2066687028 @default.
- W2068662209 cites W2068993244 @default.
- W2068662209 cites W2070277010 @default.
- W2068662209 cites W2071359470 @default.
- W2068662209 cites W2072447647 @default.
- W2068662209 cites W2074385487 @default.
- W2068662209 cites W2074581529 @default.
- W2068662209 cites W2075652092 @default.
- W2068662209 cites W2077996409 @default.
- W2068662209 cites W2078166071 @default.
- W2068662209 cites W2080478852 @default.
- W2068662209 cites W2088307620 @default.
- W2068662209 cites W2089351762 @default.
- W2068662209 cites W2091865834 @default.
- W2068662209 cites W2092669952 @default.
- W2068662209 cites W2098341193 @default.
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- W2068662209 cites W2122037734 @default.
- W2068662209 cites W2124826487 @default.
- W2068662209 cites W2126050517 @default.
- W2068662209 cites W2133623572 @default.
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- W2068662209 cites W2416782897 @default.
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- W2068662209 doi "https://doi.org/10.1016/j.neuropharm.2015.02.027" @default.
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