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• W2068665445 startingPage "58" @default.
• W2068665445 abstract "Evolution has favored the utilization of dioxygen (O2) in the development of complex multicellular organisms. O2 is actually a toxic mutagenic gas that is highly oxidizing and combustible. It is thought that plants are largely to blame for polluting the earth′s atmosphere with O2 owing to the development of photosynthesis by blue-green algae over 2 billion years ago. The rise of the plants and atmospheric O2 levels placed evolutionary stress on organisms to adapt or become extinct. This implies that all the surviving creatures on our planet are mutants that have adapted to the “abnormal biology” of O2. Much of the adaptation to the presence of O2 in biological systems comes from well-coordinated antioxidant and repair systems that focus on converting O2 to its most reduced form, water (H2O), and the repair and replacement of damaged cellular macromolecules. Biological systems have also harnessed O2′s reactive properties for energy production, xenobiotic metabolism, and host defense and as a signaling messenger and redox modulator of a number of cell signaling pathways. Many of these systems involve electron transport systems and offer many different mechanisms by which antioxidant therapeutics can alternatively produce an antioxidant effect without directly scavenging oxygen-derived reactive species. It is likely that each agent will have a different set of mechanisms that may change depending on the model of oxidative stress, organ system, or disease state. An important point is that all biological processes of aerobes have coevolved with O2 and this creates a Pandora′s box for trying to understand the mechanism(s) of action of antioxidants being developed as therapeutic agents." @default.
• W2068665445 created "2016-06-24" @default.
• W2068665445 creator A5062430469 @default.
• W2068665445 date "2014-01-01" @default.
• W2068665445 modified "2023-10-18" @default.
• W2068665445 title "Antioxidant therapeutics: Pandora′s box" @default.
• W2068665445 cites W1480587960 @default.
• W2068665445 cites W1532066573 @default.
• W2068665445 cites W1533259206 @default.
• W2068665445 cites W1605841758 @default.
• W2068665445 cites W1722710005 @default.
• W2068665445 cites W1821918060 @default.
• W2068665445 cites W1911339081 @default.
• W2068665445 cites W1965180921 @default.
• W2068665445 cites W1966698911 @default.
• W2068665445 cites W1967996072 @default.
• W2068665445 cites W1969418532 @default.
• W2068665445 cites W1971517041 @default.
• W2068665445 cites W1972198972 @default.
• W2068665445 cites W1973058491 @default.
• W2068665445 cites W1973667551 @default.
• W2068665445 cites W1977609087 @default.
• W2068665445 cites W1979225310 @default.
• W2068665445 cites W1985579798 @default.
• W2068665445 cites W1987096917 @default.
• W2068665445 cites W1987810371 @default.
• W2068665445 cites W1988069129 @default.
• W2068665445 cites W1988268961 @default.
• W2068665445 cites W1990253499 @default.
• W2068665445 cites W1990465549 @default.
• W2068665445 cites W1991437749 @default.
• W2068665445 cites W1993198896 @default.
• W2068665445 cites W1993839684 @default.
• W2068665445 cites W1996737152 @default.
• W2068665445 cites W2000887216 @default.
• W2068665445 cites W2002193577 @default.
• W2068665445 cites W2002307866 @default.
• W2068665445 cites W2005568856 @default.
• W2068665445 cites W2005868568 @default.
• W2068665445 cites W2008254936 @default.
• W2068665445 cites W2010411437 @default.
• W2068665445 cites W2013934216 @default.
• W2068665445 cites W2016231068 @default.
• W2068665445 cites W2019909669 @default.
• W2068665445 cites W2021691817 @default.
• W2068665445 cites W2023627397 @default.
• W2068665445 cites W2027179806 @default.
• W2068665445 cites W2027529665 @default.
• W2068665445 cites W2030575063 @default.
• W2068665445 cites W2031679199 @default.
• W2068665445 cites W2032498368 @default.
• W2068665445 cites W2034453401 @default.
• W2068665445 cites W2036451354 @default.
• W2068665445 cites W2040921382 @default.
• W2068665445 cites W2041116296 @default.
• W2068665445 cites W2045371968 @default.
• W2068665445 cites W2046053045 @default.
• W2068665445 cites W2051971958 @default.
• W2068665445 cites W2054571187 @default.
• W2068665445 cites W2056833906 @default.
• W2068665445 cites W2057675216 @default.
• W2068665445 cites W2058137293 @default.
• W2068665445 cites W2058557593 @default.
• W2068665445 cites W2062198930 @default.
• W2068665445 cites W2064468843 @default.
• W2068665445 cites W2064922121 @default.
• W2068665445 cites W2066137233 @default.
• W2068665445 cites W2072131913 @default.
• W2068665445 cites W2072854658 @default.
• W2068665445 cites W2073260254 @default.
• W2068665445 cites W2075266560 @default.
• W2068665445 cites W2075288834 @default.
• W2068665445 cites W2076184158 @default.
• W2068665445 cites W2076605211 @default.
• W2068665445 cites W2080224431 @default.
• W2068665445 cites W2083670406 @default.
• W2068665445 cites W2084723599 @default.
• W2068665445 cites W2085850488 @default.
• W2068665445 cites W2087284330 @default.
• W2068665445 cites W2087957280 @default.
• W2068665445 cites W2089097264 @default.
• W2068665445 cites W2093970469 @default.
• W2068665445 cites W2094860156 @default.
• W2068665445 cites W2097904015 @default.
• W2068665445 cites W2099604330 @default.
• W2068665445 cites W2101444644 @default.
• W2068665445 cites W2101645278 @default.
• W2068665445 cites W2104229795 @default.
• W2068665445 cites W2112205141 @default.
• W2068665445 cites W2112906433 @default.
• W2068665445 cites W2116889376 @default.
• W2068665445 cites W2118583516 @default.
• W2068665445 cites W2124433916 @default.
• W2068665445 cites W2124765964 @default.
• W2068665445 cites W2126614953 @default.
• W2068665445 cites W2127597194 @default.
• W2068665445 cites W2129912243 @default.
• W2068665445 cites W2130933110 @default.

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