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- W2068669077 abstract "Naturally occurring β-lactam compounds fall into four basic structural groups, the penicillins/cephalosporins, the clavams, the carbapenems and the monocyclic β-lactams. Biosynthetic studies have clarified the steps involved in the formation of the β-lactam ring for the first three of these groups, but the corresponding process or processes for the monocyclic β-lactams remains obscure. Isopenicillin N synthase is responsible for formation of the β-lactam ring in all penicillin/cephalosporin compounds, and the reaction catalyzed is completely separate from that of β-lactam synthetase, the enzyme responsible for ring formation in all clavam compounds. Conversely, carbapenam synthetase, the enzyme responsible for β-lactam ring formation for all carbapenem compounds, shows clear relatedness to β-lactam synthetase, despite differences in the substrates and the products for the two enzymes. The mechanism of ring formation has not yet been clarified for any of the monocyclic β-lactams, but a third distinct mechanism of β-lactam ring formation seems likely, and this group includes such a diverse collection of structures that even more new ring-forming reactions may be involved." @default.
- W2068669077 created "2016-06-24" @default.
- W2068669077 creator A5010971731 @default.
- W2068669077 creator A5020763283 @default.
- W2068669077 date "2013-03-27" @default.
- W2068669077 modified "2023-09-24" @default.
- W2068669077 title "Origins of the β-lactam rings in natural products" @default.
- W2068669077 cites W1483427384 @default.
- W2068669077 cites W1483806268 @default.
- W2068669077 cites W1592605778 @default.
- W2068669077 cites W1644350565 @default.
- W2068669077 cites W175873098 @default.
- W2068669077 cites W180001229 @default.
- W2068669077 cites W1839725120 @default.
- W2068669077 cites W1966039682 @default.
- W2068669077 cites W1978424514 @default.
- W2068669077 cites W1978909060 @default.
- W2068669077 cites W1979054979 @default.
- W2068669077 cites W1979492338 @default.
- W2068669077 cites W1986401742 @default.
- W2068669077 cites W1988945312 @default.
- W2068669077 cites W1990633945 @default.
- W2068669077 cites W1991144086 @default.
- W2068669077 cites W1997940970 @default.
- W2068669077 cites W1999523287 @default.
- W2068669077 cites W2000187765 @default.
- W2068669077 cites W2002637334 @default.
- W2068669077 cites W2004748707 @default.
- W2068669077 cites W2005394492 @default.
- W2068669077 cites W2011589735 @default.
- W2068669077 cites W2013090264 @default.
- W2068669077 cites W2013226839 @default.
- W2068669077 cites W2013712089 @default.
- W2068669077 cites W2013749413 @default.
- W2068669077 cites W2015949365 @default.
- W2068669077 cites W2017391914 @default.
- W2068669077 cites W2017411404 @default.
- W2068669077 cites W2017682916 @default.
- W2068669077 cites W2017981874 @default.
- W2068669077 cites W2019982170 @default.
- W2068669077 cites W2022777966 @default.
- W2068669077 cites W2024615106 @default.
- W2068669077 cites W2026461709 @default.
- W2068669077 cites W2028054320 @default.
- W2068669077 cites W2030966943 @default.
- W2068669077 cites W2036197807 @default.
- W2068669077 cites W2038146608 @default.
- W2068669077 cites W2042167402 @default.
- W2068669077 cites W2043894510 @default.
- W2068669077 cites W2047709322 @default.
- W2068669077 cites W2049174459 @default.
- W2068669077 cites W2053822489 @default.
- W2068669077 cites W2054341960 @default.
- W2068669077 cites W2057103261 @default.
- W2068669077 cites W2057222541 @default.
- W2068669077 cites W2058995008 @default.
- W2068669077 cites W2059112748 @default.
- W2068669077 cites W2059974383 @default.
- W2068669077 cites W2061759594 @default.
- W2068669077 cites W2068961731 @default.
- W2068669077 cites W2069257208 @default.
- W2068669077 cites W2069640968 @default.
- W2068669077 cites W2070479688 @default.
- W2068669077 cites W2075839804 @default.
- W2068669077 cites W2078687596 @default.
- W2068669077 cites W2079036469 @default.
- W2068669077 cites W2084368249 @default.
- W2068669077 cites W2085233290 @default.
- W2068669077 cites W2090316071 @default.
- W2068669077 cites W2091365486 @default.
- W2068669077 cites W2093586337 @default.
- W2068669077 cites W2097238178 @default.
- W2068669077 cites W2104994232 @default.
- W2068669077 cites W2117672149 @default.
- W2068669077 cites W2125984807 @default.
- W2068669077 cites W2129779495 @default.
- W2068669077 cites W2132632499 @default.
- W2068669077 cites W2144099398 @default.
- W2068669077 cites W2147414892 @default.
- W2068669077 cites W2148464225 @default.
- W2068669077 cites W2150116841 @default.
- W2068669077 cites W2316058694 @default.
- W2068669077 cites W2332918146 @default.
- W2068669077 cites W2333403824 @default.
- W2068669077 cites W2335699575 @default.
- W2068669077 cites W2338151994 @default.
- W2068669077 cites W24471328 @default.
- W2068669077 cites W42369723 @default.
- W2068669077 cites W4247390814 @default.
- W2068669077 cites W453666444 @default.
- W2068669077 doi "https://doi.org/10.1038/ja.2013.24" @default.
- W2068669077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23531986" @default.
- W2068669077 hasPublicationYear "2013" @default.
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