Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068673312> ?p ?o ?g. }
- W2068673312 endingPage "3562" @default.
- W2068673312 startingPage "3554" @default.
- W2068673312 abstract "Loss of full-length Brca1 in mammary epithelial cells of the mouse mammary tumor virus (MMTV)-Cre Brca1 conditional exon 11 deletion mouse model results in the development of mammary adenocarcinomas with similar genetic changes to those found in human BRCA1-mutation-related breast cancers. We used this experimental model to evaluate the chemopreventive effect of tamoxifen on the development of mammary preneoplasia and adenocarcinoma. No protective effects of tamoxifen administration on mammary cancer development were found. Instead, tamoxifen treatment significantly increased rates of mammary epithelial cell proliferation and the prevalence of mammary hyperplasia at 6 months of age. Tamoxifen-exposed mice developed adenocarcinomas at younger ages than control mice and a higher percentage of mice developed adenocarcinomas by 12 months of age. Both whole mouse and tissue culture cell models were used to test if loss of full-length Brca1 was associated with a relative increase in the agonist activity of tamoxifen. Tamoxifen induced increased ductal growth in MMTV-Cre Brca1 conditional mice compared to wild type. Estrogen receptor alpha (ERα) expression was downregulated in the tamoxifen-induced hyperplasias. Reducing BRCA1 levels in MCF-7 cells using siRNA resulted in a relative increase in the agonist activity of tamoxifen. Results suggest a model of mammary cancer progression in which loss of full-length Brca1 altered the agonist/antagonist activity of tamoxifen, resulting in tamoxifen-induced mammary epithelial cell proliferation with subsequent loss of ERα expression and development of ERα-negative hyperplasias and adenocarcinomas." @default.
- W2068673312 created "2016-06-24" @default.
- W2068673312 creator A5008854210 @default.
- W2068673312 creator A5014024059 @default.
- W2068673312 creator A5017851498 @default.
- W2068673312 creator A5022046028 @default.
- W2068673312 creator A5030889614 @default.
- W2068673312 creator A5042728490 @default.
- W2068673312 creator A5050911555 @default.
- W2068673312 creator A5053625755 @default.
- W2068673312 creator A5085173643 @default.
- W2068673312 date "2005-03-07" @default.
- W2068673312 modified "2023-10-10" @default.
- W2068673312 title "Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer" @default.
- W2068673312 cites W1966538470 @default.
- W2068673312 cites W1979887383 @default.
- W2068673312 cites W1979892206 @default.
- W2068673312 cites W1982445955 @default.
- W2068673312 cites W1983124590 @default.
- W2068673312 cites W1984237191 @default.
- W2068673312 cites W1985193538 @default.
- W2068673312 cites W1993337285 @default.
- W2068673312 cites W1995821399 @default.
- W2068673312 cites W2006220416 @default.
- W2068673312 cites W2009074196 @default.
- W2068673312 cites W2024682444 @default.
- W2068673312 cites W2027828801 @default.
- W2068673312 cites W2033458863 @default.
- W2068673312 cites W2033556486 @default.
- W2068673312 cites W2038793520 @default.
- W2068673312 cites W2039871782 @default.
- W2068673312 cites W2045733577 @default.
- W2068673312 cites W2046809735 @default.
- W2068673312 cites W2067916556 @default.
- W2068673312 cites W2077655442 @default.
- W2068673312 cites W2086309252 @default.
- W2068673312 cites W2095296391 @default.
- W2068673312 cites W2098294628 @default.
- W2068673312 cites W2100401891 @default.
- W2068673312 cites W2101791074 @default.
- W2068673312 cites W2101936214 @default.
- W2068673312 cites W2109388713 @default.
- W2068673312 cites W2116010079 @default.
- W2068673312 cites W2116554987 @default.
- W2068673312 cites W2117900168 @default.
- W2068673312 cites W2126679757 @default.
- W2068673312 cites W2133670454 @default.
- W2068673312 cites W2134302753 @default.
- W2068673312 cites W2137234779 @default.
- W2068673312 cites W2145703637 @default.
- W2068673312 cites W2156712240 @default.
- W2068673312 cites W2159288881 @default.
- W2068673312 cites W2160261947 @default.
- W2068673312 cites W2162110703 @default.
- W2068673312 cites W4234981523 @default.
- W2068673312 cites W4237962168 @default.
- W2068673312 cites W4253807914 @default.
- W2068673312 doi "https://doi.org/10.1038/sj.onc.1208426" @default.
- W2068673312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15750629" @default.
- W2068673312 hasPublicationYear "2005" @default.
- W2068673312 type Work @default.
- W2068673312 sameAs 2068673312 @default.
- W2068673312 citedByCount "56" @default.
- W2068673312 countsByYear W20686733122012 @default.
- W2068673312 countsByYear W20686733122013 @default.
- W2068673312 countsByYear W20686733122014 @default.
- W2068673312 countsByYear W20686733122015 @default.
- W2068673312 countsByYear W20686733122016 @default.
- W2068673312 countsByYear W20686733122017 @default.
- W2068673312 countsByYear W20686733122018 @default.
- W2068673312 countsByYear W20686733122022 @default.
- W2068673312 crossrefType "journal-article" @default.
- W2068673312 hasAuthorship W2068673312A5008854210 @default.
- W2068673312 hasAuthorship W2068673312A5014024059 @default.
- W2068673312 hasAuthorship W2068673312A5017851498 @default.
- W2068673312 hasAuthorship W2068673312A5022046028 @default.
- W2068673312 hasAuthorship W2068673312A5030889614 @default.
- W2068673312 hasAuthorship W2068673312A5042728490 @default.
- W2068673312 hasAuthorship W2068673312A5050911555 @default.
- W2068673312 hasAuthorship W2068673312A5053625755 @default.
- W2068673312 hasAuthorship W2068673312A5085173643 @default.
- W2068673312 hasBestOaLocation W20686733121 @default.
- W2068673312 hasConcept C121608353 @default.
- W2068673312 hasConcept C126322002 @default.
- W2068673312 hasConcept C134018914 @default.
- W2068673312 hasConcept C170493617 @default.
- W2068673312 hasConcept C2776067312 @default.
- W2068673312 hasConcept C2776187077 @default.
- W2068673312 hasConcept C2777164284 @default.
- W2068673312 hasConcept C2777176818 @default.
- W2068673312 hasConcept C2777562237 @default.
- W2068673312 hasConcept C2778001805 @default.
- W2068673312 hasConcept C2778938600 @default.
- W2068673312 hasConcept C2781182431 @default.
- W2068673312 hasConcept C502942594 @default.
- W2068673312 hasConcept C530470458 @default.
- W2068673312 hasConcept C54355233 @default.
- W2068673312 hasConcept C62112901 @default.