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- W2068674690 abstract "There is an emerging body of research demonstrating that the co-expression of key lineage-specifying transcription factors, commonly referred to as 'master regulators', affects the functional capabilities and flexibility of CD4(+) T cell subsets. Here, we discuss how the natural co-expression of these lineage-specifying transcription factors has challenged the concept that the expression of a single 'master regulator' strictly establishes an absolute CD4(+) T cell phenotype. Instead, it is becoming clear that the interplay between the lineage-specifying (or lineage-defining) transcription factors, including T-bet, GATA3, RORγt, BCL-6 and FOXP3, contributes to the fate and flexibility of CD4(+) T cell subtypes. This in turn has led to the realization that CD4(+) T cell phenotypes are more diverse than previously recognized." @default.
- W2068674690 created "2016-06-24" @default.
- W2068674690 creator A5053205953 @default.
- W2068674690 creator A5084845265 @default.
- W2068674690 date "2012-10-12" @default.
- W2068674690 modified "2023-10-03" @default.
- W2068674690 title "Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors" @default.
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- W2068674690 doi "https://doi.org/10.1038/nri3321" @default.
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