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- W2068677212 abstract "Tianeptine is a clinically used antidepressant that has drawn much attention, because this compound challenges traditional monoaminergic hypotheses of depression. It is now acknowledged that the antidepressant actions of tianeptine, together with its remarkable clinical tolerance, can be attributed to its particular neurobiological properties. The involvement of glutamate in the mechanism of action of the antidepressant tianeptine is consistent with a well-developed preclinical literature demonstrating the key function of glutamate in the mechanism of altered neuroplasticity that underlies the symptoms of depression. This article reviews the latest evidence on tianeptine's mechanism of action with a focus on the glutamatergic system, which could provide a key pathway for its antidepressant action. Converging lines of evidences demonstrate actions of tianeptine on the glutamatergic system, and therefore offer new insights into how tianeptine may be useful in the treatment of depressive disorders." @default.
- W2068677212 created "2016-06-24" @default.
- W2068677212 creator A5000059723 @default.
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- W2068677212 creator A5036290198 @default.
- W2068677212 creator A5036364090 @default.
- W2068677212 creator A5038762107 @default.
- W2068677212 date "2009-08-25" @default.
- W2068677212 modified "2023-10-15" @default.
- W2068677212 title "The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation" @default.
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