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- W2068678712 abstract "Nonsteroidal anti-inflammatory drugs represent 1 of the most widely prescribed drugs used for treatment of pain and inflammation. The prescription of current existing anti-inflammatory drugs is hampered by their adverse effects over time. In the recent years, there is an upsurge in the areas related to newer developments in the prevention of disease especially the role of free radicals and antioxidants. Phenolic compounds are receiving increased attention as epidemiologic studies have highlighted the association between the consumption of polyphenolic–rich food and beverages and the prevention of various human diseases. The present study investigated the analgesic and anti-inflammatory effects of chlorogenic acid (CGA), a polyphenolic compound present in many foods and beverages using carrageenan (Carr)-induced paw edema in rats and formalin – induce analgesia in mice. Swiss mice (25–35 g) and Wistar rats (180–220 g), were used, chemicals and drugs (Formalin, Carrageenan, Indomethacin, CGA). Elisa Kits were used to study the effect of CGA on Carr-induced paw edema, 0.1 mL of 1% suspension of Carr in 0.9% Nacl solution was injected. The antinociceptive effects of CGA were tested by the formalin- induced hindpaw licking procedure in the day light. Elisa Kits were used to study the effects of CGA on some indices of oxidative stress. Reduced Glutathione and Malondialdehyde in paw tissues. Treatment of rats with CGA (50, 100, 150 mg/kg) significantly reduced the rats paw edema induced by Carr and the formalin- induced pain in mice (P < 0.05) as compared with control groups. A significant reduction in rat paw volume in nitric oxide induced edema was observed (P < 0.05).CGA produced a significant reduction in malondialdehyde and significant increase in reduced glutathione in paw tissues (P < 0.05). These results confirm that CGA has both analgesic and anti-inflammatory properties that may be related to the ability of this polyphenol to reduce the levels of superoxide and peroxynitrite anion radicals. CGA showed a promising potential drug of natural anti-inflammatory property to control oxidative stress." @default.
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- W2068678712 date "2013-08-01" @default.
- W2068678712 modified "2023-09-27" @default.
- W2068678712 title "PP257—Chlorogenic acid as potential anti-inflammatory analgesic agent" @default.
- W2068678712 doi "https://doi.org/10.1016/j.clinthera.2013.07.288" @default.
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