FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068683449> ?p ?o ?g. }

• W2068683449 endingPage "1176" @default.
• W2068683449 startingPage "1166" @default.
• W2068683449 abstract "The process of aging has recently been shown to substantially affect the ability of cells to respond to inflammatory challenges. We demonstrate that aging leads to hepatic hyperresponsiveness to interleukin 1beta (IL-1beta), and we examine the factors that could be responsible for this phenomenon. IL-1beta-induced phosphorylation of c-jun N-terminal kinase (JNK) in hepatocytes isolated from aged rats was 3 times more potent than that in hepatocytes from young rats. Moreover, JNK was activated by substantially lower doses of IL-1beta. These age-related changes in JNK phosphorylation correlated with diminished IL-1beta-induced degradation of interleukin-1 receptor-associated kinase-1 (IRAK-1). Expression levels of IL1beta receptor I, total JNK, IRAK-1, and transforming growth factor-beta-activated kinase-1 (TAK-1) were not affected by aging. However, increased neutral sphingomyelinase activity was observed in hepatocytes from old animals, which we show is caused by induction of the plasma membrane localized neutral sphingomyelinase-2 (NSMase-2). We provide evidence that NSMase-2 is both required and sufficient for the onset of IL-1beta hyperresponsiveness during aging. Overexpression of NSMase-2 in hepatocytes from young rats leads both to a reduction in IRAK-1 degradation and potentiation of JNK phosphorylation, mimicking that seen in hepatocytes from old animals. More importantly, inhibition of NSMase activity in hepatocytes from aged rats using either scyphostatin or short interfering ribonucleic acid (siRNA) leads to reversion to the young phenotype of IL-1beta response.These results show that the process of aging causes increased basal NSMase-2 activity in hepatocytes, which in turn leads to IRAK-1 stabilization, JNK potentiation, and ultimately IL-1beta hyperresponsiveness." @default.
• W2068683449 created "2016-06-24" @default.
• W2068683449 creator A5034244248 @default.
• W2068683449 creator A5045293390 @default.
• W2068683449 creator A5051804831 @default.
• W2068683449 creator A5066374603 @default.
• W2068683449 creator A5070557696 @default.
• W2068683449 date "2007-01-01" @default.
• W2068683449 modified "2023-09-24" @default.
• W2068683449 title "Aging in rat causes hepatic hyperresposiveness to interleukin-1β which is mediated by neutral sphingomyelinase-2" @default.
• W2068683449 cites W1506299568 @default.
• W2068683449 cites W1535452588 @default.
• W2068683449 cites W1538201785 @default.
• W2068683449 cites W1575383081 @default.
• W2068683449 cites W1607100760 @default.
• W2068683449 cites W1968784427 @default.
• W2068683449 cites W1969158591 @default.
• W2068683449 cites W1969501356 @default.
• W2068683449 cites W1982533264 @default.
• W2068683449 cites W1987467392 @default.
• W2068683449 cites W1988296387 @default.
• W2068683449 cites W2003598465 @default.
• W2068683449 cites W2004986546 @default.
• W2068683449 cites W2006077299 @default.
• W2068683449 cites W2006923351 @default.
• W2068683449 cites W2009635211 @default.
• W2068683449 cites W2011211995 @default.
• W2068683449 cites W2012828106 @default.
• W2068683449 cites W2013036626 @default.
• W2068683449 cites W2015649813 @default.
• W2068683449 cites W2019256890 @default.
• W2068683449 cites W2025595360 @default.
• W2068683449 cites W2031581424 @default.
• W2068683449 cites W2035217892 @default.
• W2068683449 cites W2037372389 @default.
• W2068683449 cites W2042223647 @default.
• W2068683449 cites W2042392347 @default.
• W2068683449 cites W2044937910 @default.
• W2068683449 cites W2055131916 @default.
• W2068683449 cites W2058124777 @default.
• W2068683449 cites W2058312167 @default.
• W2068683449 cites W2060090974 @default.
• W2068683449 cites W2064434771 @default.
• W2068683449 cites W2064439294 @default.
• W2068683449 cites W2064558057 @default.
• W2068683449 cites W2071944650 @default.
• W2068683449 cites W2092699086 @default.
• W2068683449 cites W2093398266 @default.
• W2068683449 cites W2097323575 @default.
• W2068683449 cites W2106098936 @default.
• W2068683449 cites W2108434241 @default.
• W2068683449 cites W2124090060 @default.
• W2068683449 cites W2128693624 @default.
• W2068683449 cites W2146858278 @default.
• W2068683449 cites W2157200858 @default.
• W2068683449 cites W2160100563 @default.
• W2068683449 cites W2161888109 @default.
• W2068683449 doi "https://doi.org/10.1002/hep.21777" @default.
• W2068683449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17668873" @default.
• W2068683449 hasPublicationYear "2007" @default.
• W2068683449 type Work @default.
• W2068683449 sameAs 2068683449 @default.
• W2068683449 citedByCount "32" @default.
• W2068683449 countsByYear W20686834492012 @default.
• W2068683449 countsByYear W20686834492013 @default.
• W2068683449 countsByYear W20686834492014 @default.
• W2068683449 countsByYear W20686834492015 @default.
• W2068683449 countsByYear W20686834492016 @default.
• W2068683449 countsByYear W20686834492017 @default.
• W2068683449 countsByYear W20686834492018 @default.
• W2068683449 countsByYear W20686834492019 @default.
• W2068683449 countsByYear W20686834492020 @default.
• W2068683449 countsByYear W20686834492021 @default.
• W2068683449 crossrefType "journal-article" @default.
• W2068683449 hasAuthorship W2068683449A5034244248 @default.
• W2068683449 hasAuthorship W2068683449A5045293390 @default.
• W2068683449 hasAuthorship W2068683449A5051804831 @default.
• W2068683449 hasAuthorship W2068683449A5066374603 @default.
• W2068683449 hasAuthorship W2068683449A5070557696 @default.
• W2068683449 hasBestOaLocation W20686834491 @default.
• W2068683449 hasConcept C104317684 @default.
• W2068683449 hasConcept C11960822 @default.
• W2068683449 hasConcept C126322002 @default.
• W2068683449 hasConcept C127716648 @default.
• W2068683449 hasConcept C134018914 @default.
• W2068683449 hasConcept C184235292 @default.
• W2068683449 hasConcept C185592680 @default.
• W2068683449 hasConcept C2778163477 @default.
• W2068683449 hasConcept C2778690821 @default.
• W2068683449 hasConcept C2781070647 @default.
• W2068683449 hasConcept C2781457462 @default.
• W2068683449 hasConcept C55493867 @default.
• W2068683449 hasConcept C61322309 @default.
• W2068683449 hasConcept C70883133 @default.
• W2068683449 hasConcept C71924100 @default.
• W2068683449 hasConcept C74172505 @default.
• W2068683449 hasConcept C86803240 @default.
• W2068683449 hasConcept C95444343 @default.

• next