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- W2068685700 abstract "Recent advances in the prevention of graft-versus-host disease through postthymic T-cell depletion have allowed the use of haploidentical bone marrow cells for immunologic reconstitution of severe combined immunodeficiency disease. We report a male infant with severe combined immunodeficiency (with normal adenosine deaminase) who developed two IgG kappa and one IgA lambda paraproteins 7 weeks following the administration of 1.4×109 maternal bone marrow cells depleted of postthymic T cells by soy lectin agglutination and sheep erythrocyte rosetting. Serum IgG rose from 128 to 820 mg/dl, and IgA from 0 to 2400 mg/dl, peaking at 10 weeks postgrafting. By 14 weeks posttransplantation T-cell numbers and function had risen to normal (all dividing T cells had the donor karyotype) and paraprotein concentrations began to decline. These observations strongly suggest that the later-appearing T cells regulated the B-cell clones from which the paraproteins were derived. Failure of such function to appear could account for the increased incidence of B-cell lymphomas in severe combined immunodeficiency." @default.
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- W2068685700 date "1985-01-01" @default.
- W2068685700 modified "2023-09-25" @default.
- W2068685700 title "339 Appearance of multiple paraproteins during early engraftment of soy lectin T cell depleted haploidentical bone marrow cells in severe combined immunodeficiency (SCID)" @default.
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- W2068685700 doi "https://doi.org/10.1016/0091-6749(85)90474-9" @default.
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