Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068690697> ?p ?o ?g. }
- W2068690697 endingPage "6087" @default.
- W2068690697 startingPage "6087" @default.
- W2068690697 abstract "A new set of ruthenium(II) hydrazone complexes [Ru(H)(CO)(PPh3)2(L)] (1) and [RuCl2(DMSO)2(HL)] (2), with triphenyl phosphine or DMSO as co-ligands was synthesized by reacting benzoyl pyridine furoic acid hydrazone (HL) with [Ru(H)(Cl)(CO)(PPh3)3] and [RuCl2(DMSO)4]. The single crystal X-ray data of complexes 1 and 2 revealed an octahedral geometry around the ruthenium ion in which the hydrazone is coordinated through ON and NN atoms in complexes 1 and 2 respectively. The interaction of the compounds with calf thymus DNA (CT-DNA) has been estimated by absorption and emission titration methods which indicated that the ligand and the complexes interacted with CT-DNA through intercalation. In addition, the DNA cleavage ability of these newly synthesized ruthenium complexes assessed by an agarose gel electrophoresis method demonstrated that complex 2 has a higher DNA cleavage activity than that of complex 1. The binding properties of the free ligand and its complexes with bovine serum albumin (BSA) protein have been investigated using UV-visible, fluorescence and synchronous fluorescence spectroscopic methods which indicated the stronger binding nature of the ruthenium complexes to BSA than the free hydrazone ligand. Furthermore, the cytotoxicity of the compounds examined in vitro on a human cervical cancer cell line (HeLa) and a normal mouse embryonic fibroblasts cell line (NIH 3T3) revealed that complex 2 exhibited a superior cytotoxicity than complex 1 to the cancer cells but was less toxic to the normal mouse embryonic fibroblasts under identical conditions." @default.
- W2068690697 created "2016-06-24" @default.
- W2068690697 creator A5024957683 @default.
- W2068690697 creator A5029944023 @default.
- W2068690697 creator A5072644626 @default.
- W2068690697 date "2014-01-01" @default.
- W2068690697 modified "2023-09-26" @default.
- W2068690697 title "An investigation on new ruthenium(ii) hydrazone complexes as anticancer agents and their interaction with biomolecules" @default.
- W2068690697 cites W173920864 @default.
- W2068690697 cites W1965272410 @default.
- W2068690697 cites W1971609340 @default.
- W2068690697 cites W1974234898 @default.
- W2068690697 cites W1981262454 @default.
- W2068690697 cites W1982029843 @default.
- W2068690697 cites W1986509921 @default.
- W2068690697 cites W1990032603 @default.
- W2068690697 cites W1993582814 @default.
- W2068690697 cites W1994073437 @default.
- W2068690697 cites W1994136277 @default.
- W2068690697 cites W2001492916 @default.
- W2068690697 cites W2005603971 @default.
- W2068690697 cites W2013436421 @default.
- W2068690697 cites W2015694743 @default.
- W2068690697 cites W2016766923 @default.
- W2068690697 cites W2017501693 @default.
- W2068690697 cites W2019125149 @default.
- W2068690697 cites W2021367505 @default.
- W2068690697 cites W2025717602 @default.
- W2068690697 cites W2028657135 @default.
- W2068690697 cites W2030173263 @default.
- W2068690697 cites W2034735042 @default.
- W2068690697 cites W2037366295 @default.
- W2068690697 cites W2040178224 @default.
- W2068690697 cites W2040184556 @default.
- W2068690697 cites W2041394701 @default.
- W2068690697 cites W2041459118 @default.
- W2068690697 cites W2044851985 @default.
- W2068690697 cites W2048854266 @default.
- W2068690697 cites W2049088667 @default.
- W2068690697 cites W2049713049 @default.
- W2068690697 cites W2049830971 @default.
- W2068690697 cites W2059205366 @default.
- W2068690697 cites W2061417686 @default.
- W2068690697 cites W2062328767 @default.
- W2068690697 cites W2062532800 @default.
- W2068690697 cites W2070724294 @default.
- W2068690697 cites W2074295848 @default.
- W2068690697 cites W2074635589 @default.
- W2068690697 cites W2077567454 @default.
- W2068690697 cites W2078034063 @default.
- W2068690697 cites W2078297328 @default.
- W2068690697 cites W2089797648 @default.
- W2068690697 cites W2090633928 @default.
- W2068690697 cites W2094102708 @default.
- W2068690697 cites W2095112147 @default.
- W2068690697 cites W2113813397 @default.
- W2068690697 cites W2114918609 @default.
- W2068690697 cites W2116177049 @default.
- W2068690697 cites W2123512355 @default.
- W2068690697 cites W2139338030 @default.
- W2068690697 cites W2148529609 @default.
- W2068690697 cites W2166689829 @default.
- W2068690697 cites W2170756410 @default.
- W2068690697 cites W2319170265 @default.
- W2068690697 cites W2324613566 @default.
- W2068690697 cites W2332024238 @default.
- W2068690697 cites W2952384035 @default.
- W2068690697 doi "https://doi.org/10.1039/c3dt51949j" @default.
- W2068690697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24519473" @default.
- W2068690697 hasPublicationYear "2014" @default.
- W2068690697 type Work @default.
- W2068690697 sameAs 2068690697 @default.
- W2068690697 citedByCount "33" @default.
- W2068690697 countsByYear W20686906972014 @default.
- W2068690697 countsByYear W20686906972015 @default.
- W2068690697 countsByYear W20686906972016 @default.
- W2068690697 countsByYear W20686906972017 @default.
- W2068690697 countsByYear W20686906972018 @default.
- W2068690697 countsByYear W20686906972019 @default.
- W2068690697 countsByYear W20686906972020 @default.
- W2068690697 countsByYear W20686906972021 @default.
- W2068690697 countsByYear W20686906972023 @default.
- W2068690697 crossrefType "journal-article" @default.
- W2068690697 hasAuthorship W2068690697A5024957683 @default.
- W2068690697 hasAuthorship W2068690697A5029944023 @default.
- W2068690697 hasAuthorship W2068690697A5072644626 @default.
- W2068690697 hasConcept C109316439 @default.
- W2068690697 hasConcept C115624301 @default.
- W2068690697 hasConcept C116569031 @default.
- W2068690697 hasConcept C137824038 @default.
- W2068690697 hasConcept C155647269 @default.
- W2068690697 hasConcept C161790260 @default.
- W2068690697 hasConcept C170493617 @default.
- W2068690697 hasConcept C178790620 @default.
- W2068690697 hasConcept C185592680 @default.
- W2068690697 hasConcept C202751555 @default.
- W2068690697 hasConcept C2777366897 @default.
- W2068690697 hasConcept C2778271344 @default.