FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068691871> ?p ?o ?g. }

• W2068691871 endingPage "2117" @default.
• W2068691871 startingPage "2109" @default.
• W2068691871 abstract "We previously reported that mice subjected to partial hepatectomy exhibit rapid development of hypoglycemia followed by transient accumulation of fat in the early regenerating liver. We also showed that disrupting these metabolic alterations results in impaired liver regeneration. The studies reported here were undertaken to further characterize and investigate the functional importance of changes in systemic adipose metabolism during normal liver regeneration. The results showed that a systemic catabolic response is induced in each of two distinct, commonly used experimental models of liver regeneration (partial hepatectomy and carbon tetrachloride treatment), and that this response occurs in proportion to the degree of induced hepatic insufficiency. Together, these observations suggest that catabolism of systemic adipose stores may be essential for normal liver regeneration. To test this possibility, we investigated the hepatic regenerative response in fatty liver dystrophy (fld) mice, which exhibit partial lipodystrophy and have diminished peripheral adipose stores. The results showed that the development of hypoglycemia and hepatic accumulation of fat was attenuated and liver regeneration was impaired following partial hepatectomy in these animals. The fld mice also exhibited increased hepatic p21 expression and diminished plasma levels of the adipose-derived hormones adiponectin and leptin, which have each been implicated as regulators of liver regeneration. Conclusion: These data suggest that the hypoglycemia that develops after partial hepatectomy induces systemic lipolysis followed by accumulation of fat derived from peripheral stores in the early regenerating liver, and that these events may be essential for initiation of normal liver regeneration. (HEPATOLOGY 2010)" @default.
• W2068691871 created "2016-06-24" @default.
• W2068691871 creator A5036761673 @default.
• W2068691871 creator A5040672707 @default.
• W2068691871 creator A5043784762 @default.
• W2068691871 creator A5051510306 @default.
• W2068691871 creator A5058200339 @default.
• W2068691871 creator A5077733127 @default.
• W2068691871 creator A5090313762 @default.
• W2068691871 date "2010-10-21" @default.
• W2068691871 modified "2023-10-17" @default.
• W2068691871 title "Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice" @default.
• W2068691871 cites W1985427987 @default.
• W2068691871 cites W1991420853 @default.
• W2068691871 cites W1996735281 @default.
• W2068691871 cites W1997400673 @default.
• W2068691871 cites W1998682759 @default.
• W2068691871 cites W2007602911 @default.
• W2068691871 cites W2008777325 @default.
• W2068691871 cites W2009008191 @default.
• W2068691871 cites W2013282373 @default.
• W2068691871 cites W2013853905 @default.
• W2068691871 cites W2025421728 @default.
• W2068691871 cites W2029260587 @default.
• W2068691871 cites W2041044388 @default.
• W2068691871 cites W2043493252 @default.
• W2068691871 cites W2044919636 @default.
• W2068691871 cites W2051778980 @default.
• W2068691871 cites W2052467994 @default.
• W2068691871 cites W2056260331 @default.
• W2068691871 cites W2058874539 @default.
• W2068691871 cites W2059891631 @default.
• W2068691871 cites W2062005522 @default.
• W2068691871 cites W2062139169 @default.
• W2068691871 cites W2088637473 @default.
• W2068691871 cites W2091459334 @default.
• W2068691871 cites W2093207418 @default.
• W2068691871 cites W2110149504 @default.
• W2068691871 cites W2117962285 @default.
• W2068691871 cites W2118529933 @default.
• W2068691871 cites W2120565320 @default.
• W2068691871 cites W2132468746 @default.
• W2068691871 cites W2140701702 @default.
• W2068691871 cites W2148403724 @default.
• W2068691871 cites W2153466153 @default.
• W2068691871 cites W2165611065 @default.
• W2068691871 cites W4210995852 @default.
• W2068691871 cites W4211173486 @default.
• W2068691871 cites W4237329722 @default.
• W2068691871 cites W89320799 @default.
• W2068691871 doi "https://doi.org/10.1002/hep.23920" @default.
• W2068691871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2991544" @default.
• W2068691871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20967828" @default.
• W2068691871 hasPublicationYear "2010" @default.
• W2068691871 type Work @default.
• W2068691871 sameAs 2068691871 @default.
• W2068691871 citedByCount "65" @default.
• W2068691871 countsByYear W20686918712012 @default.
• W2068691871 countsByYear W20686918712013 @default.
• W2068691871 countsByYear W20686918712014 @default.
• W2068691871 countsByYear W20686918712015 @default.
• W2068691871 countsByYear W20686918712016 @default.
• W2068691871 countsByYear W20686918712018 @default.
• W2068691871 countsByYear W20686918712019 @default.
• W2068691871 countsByYear W20686918712020 @default.
• W2068691871 countsByYear W20686918712021 @default.
• W2068691871 countsByYear W20686918712022 @default.
• W2068691871 countsByYear W20686918712023 @default.
• W2068691871 crossrefType "journal-article" @default.
• W2068691871 hasAuthorship W2068691871A5036761673 @default.
• W2068691871 hasAuthorship W2068691871A5040672707 @default.
• W2068691871 hasAuthorship W2068691871A5043784762 @default.
• W2068691871 hasAuthorship W2068691871A5051510306 @default.
• W2068691871 hasAuthorship W2068691871A5058200339 @default.
• W2068691871 hasAuthorship W2068691871A5077733127 @default.
• W2068691871 hasAuthorship W2068691871A5090313762 @default.
• W2068691871 hasBestOaLocation W20686918711 @default.
• W2068691871 hasConcept C126322002 @default.
• W2068691871 hasConcept C134018914 @default.
• W2068691871 hasConcept C140985366 @default.
• W2068691871 hasConcept C141071460 @default.
• W2068691871 hasConcept C159110652 @default.
• W2068691871 hasConcept C171056886 @default.
• W2068691871 hasConcept C171089720 @default.
• W2068691871 hasConcept C2776782570 @default.
• W2068691871 hasConcept C2776795407 @default.
• W2068691871 hasConcept C2776909242 @default.
• W2068691871 hasConcept C2777391703 @default.
• W2068691871 hasConcept C2778772119 @default.
• W2068691871 hasConcept C2779134260 @default.
• W2068691871 hasConcept C2779306644 @default.
• W2068691871 hasConcept C41260117 @default.
• W2068691871 hasConcept C44353895 @default.
• W2068691871 hasConcept C71924100 @default.
• W2068691871 hasConcept C86803240 @default.
• W2068691871 hasConcept C95444343 @default.
• W2068691871 hasConceptScore W2068691871C126322002 @default.
• W2068691871 hasConceptScore W2068691871C134018914 @default.

• next