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• W2068692772 abstract "To evaluate the antiviral response of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) patients who had baseline high viral load (HVL), defined as having hepatitis B virus (HBV) DNA > 9 log 10 copies/mL, after 96 weeks of entecavir (ETV) treatment. A total of 99 HBeAg-positive CHB patients (50 with HVL and 49 with non-HVL) were treated with ETV monotherapy for 96 weeks. Virological response (VR) (HBVDNA < 300 copies/mL) was achieved in 42%, 62%, 68% of HVL patients and in 67.34%, 85.71%, 85.71% of non-HVL patients at weeks 48,72,96, respectively. The VR rates of the HVL group were lower than those of the non-HVL group (P = 0.006, P = 0.007, and P = 0.037). In the HVL group, a total of 30 patients had HBV DNA < 1000 copies/mL at week 48 and those patients had a 93.3% chance of achieving VR at week 96, whereas the patients who had HBV DNA levels > 1000 copies/mL at week 48 only had a 30% chance to achieve VR at week 96. Among the 96 weeks of treatment, one patient had virological breakthrough in the HVL group and this patient had HBVDNA > 1000 copies/mL at week 48. The rates of biochemical responses (BR) and HBeAg seroconversion (SR) were similar between the HVL group and non-HVL group at weeks 48 and 96. The baseline HVL was a negative predictor of virological response in CHB patients with ETV monotherapy. For those HVL patients treated by ETV with poor VR, which defined as HBVDNA > 1000 copies/mL at week 48, the treatment strategies need to be adjusted." @default.
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• W2068692772 date "2015-06-01" @default.
• W2068692772 modified "2023-10-18" @default.
• W2068692772 title "Efficacy of entecavir treatment for up to 96 weeks in nucleoside-naive HBeAg-positive chronic hepatitis B patients with high viral load" @default.
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• W2068692772 doi "https://doi.org/10.1016/j.clinre.2014.09.009" @default.
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