FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068694954> ?p ?o ?g. }

• W2068694954 endingPage "640" @default.
• W2068694954 startingPage "631" @default.
• W2068694954 abstract "The effects of grisorixin, a monocarboxylic ionophore, were studied on isolated working rat hearts perfused with a suspension of washed pig erythrocytes (10% hematocrit). Grisorixin (2.5 μM) induced a transient stimulation of heart work, maximal at 5 min, expressed by an increase in heart rate (+21%) and aortic flow (+17%) and by an increase in coronary flow, maximal at 10 min (+47%). Concomitantly, myocardial [Formula: see text] was slightly enhanced and the myocardial creatine phosphate level dropped (2 min). The lactate production increased by 82% (5 min) then dropped to the control value (10 min) and increased again till the 45th min (+211%), indicating a cardiac metabolic drift towards anaerobic glycolysis due to partial inhibition of the oxidative metabolism. Owing to its properties as an ionophore, grisorixin also induced a strong and rapid increase of potassium concentration in the perfusate and a decrease of sodium. Grisorixin was tested on hearts submitted to 20 min of hypoxic conditions. The hypoxia was rather mild and induced only very slight modifications of the ultrastructure. In the control series, heart rate and aortic flow decreased regularly while coronary flow and lactate production increased. Upon reoxygenation, the heart performances were rapidly restored. Grisorixin was administered according to four different protocols. When injected at the onset of hypoxia or 5 min later, it was able to maintain the aortic flow during the first minutes and induce a higher coronary dilation. These beneficial effects were short-lasting and no deleterious effects were found on the ultrastructure of hearts subjected to grisorixin whether after hypoxia or after reoxygenation." @default.
• W2068694954 created "2016-06-24" @default.
• W2068694954 creator A5038489193 @default.
• W2068694954 creator A5061916271 @default.
• W2068694954 creator A5079184779 @default.
• W2068694954 creator A5088504545 @default.
• W2068694954 date "1986-05-01" @default.
• W2068694954 modified "2023-10-04" @default.
• W2068694954 title "Effects of the ionophore grisorixin on myocardial function and metabolism in isolated perfused working rat heart under normoxic and hypoxic conditions" @default.
• W2068694954 cites W1565056239 @default.
• W2068694954 cites W1566830427 @default.
• W2068694954 cites W1592408832 @default.
• W2068694954 cites W1946762499 @default.
• W2068694954 cites W1951580423 @default.
• W2068694954 cites W1958138038 @default.
• W2068694954 cites W1968917531 @default.
• W2068694954 cites W1979369244 @default.
• W2068694954 cites W1983780865 @default.
• W2068694954 cites W1984937440 @default.
• W2068694954 cites W1999074035 @default.
• W2068694954 cites W2014538668 @default.
• W2068694954 cites W2016822721 @default.
• W2068694954 cites W2017736518 @default.
• W2068694954 cites W2023637753 @default.
• W2068694954 cites W2030655590 @default.
• W2068694954 cites W2031001028 @default.
• W2068694954 cites W2049180079 @default.
• W2068694954 cites W2073258262 @default.
• W2068694954 cites W2079069893 @default.
• W2068694954 cites W2090210229 @default.
• W2068694954 cites W2132232598 @default.
• W2068694954 cites W2141574179 @default.
• W2068694954 cites W2144537953 @default.
• W2068694954 cites W2147478560 @default.
• W2068694954 cites W2174107598 @default.
• W2068694954 cites W223313223 @default.
• W2068694954 cites W2235913420 @default.
• W2068694954 cites W2408082826 @default.
• W2068694954 cites W2485811354 @default.
• W2068694954 cites W388784978 @default.
• W2068694954 cites W1958468327 @default.
• W2068694954 doi "https://doi.org/10.1139/y86-105" @default.
• W2068694954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3730948" @default.
• W2068694954 hasPublicationYear "1986" @default.
• W2068694954 type Work @default.
• W2068694954 sameAs 2068694954 @default.
• W2068694954 citedByCount "2" @default.
• W2068694954 crossrefType "journal-article" @default.
• W2068694954 hasAuthorship W2068694954A5038489193 @default.
• W2068694954 hasAuthorship W2068694954A5061916271 @default.
• W2068694954 hasAuthorship W2068694954A5079184779 @default.
• W2068694954 hasAuthorship W2068694954A5088504545 @default.
• W2068694954 hasConcept C126322002 @default.
• W2068694954 hasConcept C134018914 @default.
• W2068694954 hasConcept C178790620 @default.
• W2068694954 hasConcept C185592680 @default.
• W2068694954 hasConcept C20251656 @default.
• W2068694954 hasConcept C2779014961 @default.
• W2068694954 hasConcept C2779896295 @default.
• W2068694954 hasConcept C2780959883 @default.
• W2068694954 hasConcept C42407357 @default.
• W2068694954 hasConcept C5140985 @default.
• W2068694954 hasConcept C519063684 @default.
• W2068694954 hasConcept C540031477 @default.
• W2068694954 hasConcept C55885012 @default.
• W2068694954 hasConcept C62231903 @default.
• W2068694954 hasConcept C71924100 @default.
• W2068694954 hasConcept C7836513 @default.
• W2068694954 hasConcept C86803240 @default.
• W2068694954 hasConceptScore W2068694954C126322002 @default.
• W2068694954 hasConceptScore W2068694954C134018914 @default.
• W2068694954 hasConceptScore W2068694954C178790620 @default.
• W2068694954 hasConceptScore W2068694954C185592680 @default.
• W2068694954 hasConceptScore W2068694954C20251656 @default.
• W2068694954 hasConceptScore W2068694954C2779014961 @default.
• W2068694954 hasConceptScore W2068694954C2779896295 @default.
• W2068694954 hasConceptScore W2068694954C2780959883 @default.
• W2068694954 hasConceptScore W2068694954C42407357 @default.
• W2068694954 hasConceptScore W2068694954C5140985 @default.
• W2068694954 hasConceptScore W2068694954C519063684 @default.
• W2068694954 hasConceptScore W2068694954C540031477 @default.
• W2068694954 hasConceptScore W2068694954C55885012 @default.
• W2068694954 hasConceptScore W2068694954C62231903 @default.
• W2068694954 hasConceptScore W2068694954C71924100 @default.
• W2068694954 hasConceptScore W2068694954C7836513 @default.
• W2068694954 hasConceptScore W2068694954C86803240 @default.
• W2068694954 hasIssue "5" @default.
• W2068694954 hasLocation W20686949541 @default.
• W2068694954 hasLocation W20686949542 @default.
• W2068694954 hasOpenAccess W2068694954 @default.
• W2068694954 hasPrimaryLocation W20686949541 @default.
• W2068694954 hasRelatedWork W1512266911 @default.
• W2068694954 hasRelatedWork W1898038862 @default.
• W2068694954 hasRelatedWork W1911454259 @default.
• W2068694954 hasRelatedWork W1978401528 @default.
• W2068694954 hasRelatedWork W2066853893 @default.
• W2068694954 hasRelatedWork W2077920541 @default.
• W2068694954 hasRelatedWork W2322521680 @default.

• next