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• W2068698961 abstract "Abstract A rare recurrent chromosomal translocation, t(14;19)(q32;q13), has been identified in a variety of B‐cell malignancies, including chronic lymphocytic leukemia ( CLL ). We report a unique case of CLL in a patient carrying both trisomy 12 and t(14;19) (q32;q13.1), in whom t(11;14)(q13;q32) developed at relapse. The patient was a 77‐yr‐old woman, and her lymphoma cells at presentation showed CD 5 + , CD 10 − , CD 19 + , CD 20 + (dim), CD 23 + , CD 38 + , and CD 11c + . At relapse, the patient's lymphoma cells showed positive staining for cyclin D1 in addition to CD 5, CD 20, and CD 23. Lymphoma cells in specimens at both presentation and relapse were positive for lymphoid enhancer factor 1 ( LEF 1) and negative for sex‐determining region Y‐box 11 ( SOX 11). IGH ‐ BCL 1 FISH became positive at relapse. Split FISH assay using BCL 1 , BCL 3 , IGH , and CCND 1 probes on lymph node specimens obtained at presentation and at autopsy confirmed that the translocation of BCL 3 was solely detected in the lymph node at presentation and detected BCL 3 and CCND 1 translocations in the specimen at autopsy. These observations indicated that IGH ‐ BCL 3 and IGH ‐ CCND 1 had occurred in the same clone after treatment of the disease. In line with immunohistochemical and cytogenetic studies, additional PCR analysis of the FR 3‐ JH region showed the same sequence derived from IGHV 4‐34 in specimens obtained at disease onset and relapse." @default.
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• W2068698961 date "2013-05-31" @default.
• W2068698961 modified "2023-10-04" @default.
• W2068698961 title "Acquisition of t(11;14) in a patient with chronic lymphocytic leukemia carrying both t(14;19)(q32;q13.1) and +12" @default.
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• W2068698961 doi "https://doi.org/10.1111/ejh.12119" @default.
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