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- W2068699102 abstract "Abstract The major challenge in allogeneic hematopoietic cell transplantation is how to transfer allogeneic T-cell immunity without causing graft-versus-host disease (GVHD). Here we report a novel strategy to selectively prevent GVHD by depleting CD62L+ T cells (naive and a subset of memory T cells). In unprimed mice, CD62L– T cells (a subset of memory T cells) failed to proliferate in response to alloantigens (which the mice have never previously encountered) and were unable to induce GVHD in allogeneic hosts. CD62L– T cells contributed to T-cell reconstitution by peripheral expansion as well as by promoting T-cell regeneration from bone marrow stem/progenitor cells. CD62L– T cells from the animals previously primed with a tumor cell line (BCL1) were able to inhibit the tumor growth in vivo but were unable to induce GVHD in the third-party recipients. This novel technology may allow transfer of allogeneic recall antitumor and antimicrobial immunity without causing GVHD." @default.
- W2068699102 created "2016-06-24" @default.
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- W2068699102 date "2004-02-15" @default.
- W2068699102 modified "2023-10-03" @default.
- W2068699102 title "Transfer of allogeneic CD62L– memory T cells without graft-versus-host disease" @default.
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- W2068699102 doi "https://doi.org/10.1182/blood-2003-08-2987" @default.
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