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- W2068702746 abstract "Some new fluorine substituted heterocyclic nitrogen systems 2–17 have been synthesized from ring closure reactions of substituted p -amino salicylic acids (PAS). The Schiffs base of PAS was cyclized with chloroacetyl chloride and mercaptoacetic acid to give azetidinone 2 , thiazolidinone 3 , and spiro-fluoroindolothiazoline-dione 10 . However, PAS when reacted directly with 4-fluorobenzoyl chloride and 5-oxazolinone yielded derivatives 4 , 5 , and 7 . Aminomethylation of PAS using formaldehyde and piperidine or piperazine formed N-alkyl and N,N′-dialkyl derivatives ( 11 and 12 respectively) upon fluorinated benzoylation gave compounds 13 and 14 . Similarly, treatment of PAS with thiosemicarbazide 15 and subsequent cyclization with diethyl oxalate yielded the fluorinated heterocycle 17 . The structures of the fluorinated heterocyclic systems have been established on the basis of elemental analysis, 1 H NMR, 13 C NMR, and MS spectral data. Some of the targets exhibited a high inhibition towards Mycobacterium strain with favorable log P values." @default.
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- W2068702746 date "2013-01-01" @default.
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- W2068702746 title "Synthesis of New Fluorine Substituted Heterocyclic Nitrogen Systems Derived fromp-Aminosalicylic Acid as Antimycobacterial Agents" @default.
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- W2068702746 doi "https://doi.org/10.1155/2013/819462" @default.
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