Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068702958> ?p ?o ?g. }
- W2068702958 endingPage "014003" @default.
- W2068702958 startingPage "014003" @default.
- W2068702958 abstract "Light and heat distributions are measured in a rat glioma model used in photodynamic therapy. A fiber delivering 632-nm light is fixed in the brain of anesthetized BDIX rats. Fluence rates are measured using calibrated isotropic probes that are positioned stereotactically. Mathematical models are then used to derive tissue optical properties, enabling calculation of fluence rate distributions for general tumor and light application geometries. The fluence rates in tumor-free brains agree well with the models based on diffusion theory and Monte Carlo simulation. In both cases, the best fit is found for absorption and reduced scattering coefficients of 0.57 and 28 cm−1, respectively. In brains with implanted BT4C tumors, a discrepancy between diffusion and Monte Carlo–derived two-layer models is noted. Both models suggest that tumor tissue has higher absorption and less scattering than normal brain. Temperatures are measured by inserting thermocouples directly into tumor-free brains. A model based on diffusion theory and the bioheat equation is found to be in good agreement with the experimental data and predict a thermal penetration depth of 0.60 cm in normal rat brain. The predicted parameters can be used to estimate the fluences, fluence rates, and temperatures achieved during photodynamic therapy." @default.
- W2068702958 created "2016-06-24" @default.
- W2068702958 creator A5009351880 @default.
- W2068702958 creator A5041948925 @default.
- W2068702958 creator A5073832291 @default.
- W2068702958 date "2007-01-01" @default.
- W2068702958 modified "2023-10-17" @default.
- W2068702958 title "Determination of fluence rate and temperature distributions in the rat brain; implications for photodynamic therapy" @default.
- W2068702958 cites W1489278279 @default.
- W2068702958 cites W1964421702 @default.
- W2068702958 cites W1981012868 @default.
- W2068702958 cites W1985110931 @default.
- W2068702958 cites W1985281199 @default.
- W2068702958 cites W1987265828 @default.
- W2068702958 cites W1992477463 @default.
- W2068702958 cites W1994460634 @default.
- W2068702958 cites W1997945654 @default.
- W2068702958 cites W2002527277 @default.
- W2068702958 cites W2005781880 @default.
- W2068702958 cites W2012848985 @default.
- W2068702958 cites W2013304348 @default.
- W2068702958 cites W2013492930 @default.
- W2068702958 cites W2031545502 @default.
- W2068702958 cites W2038354528 @default.
- W2068702958 cites W2041608170 @default.
- W2068702958 cites W2041706696 @default.
- W2068702958 cites W2042172629 @default.
- W2068702958 cites W2047616560 @default.
- W2068702958 cites W2049000184 @default.
- W2068702958 cites W2049730553 @default.
- W2068702958 cites W2050054249 @default.
- W2068702958 cites W2063342408 @default.
- W2068702958 cites W2065200530 @default.
- W2068702958 cites W2065744257 @default.
- W2068702958 cites W2072412815 @default.
- W2068702958 cites W2074531748 @default.
- W2068702958 cites W2080786676 @default.
- W2068702958 cites W2085658304 @default.
- W2068702958 cites W2090400176 @default.
- W2068702958 cites W2143506792 @default.
- W2068702958 cites W2167377056 @default.
- W2068702958 cites W2169069141 @default.
- W2068702958 cites W2169220299 @default.
- W2068702958 cites W2220109084 @default.
- W2068702958 cites W2438692934 @default.
- W2068702958 cites W4211024586 @default.
- W2068702958 cites W4239526824 @default.
- W2068702958 cites W4247165062 @default.
- W2068702958 cites W4247733704 @default.
- W2068702958 cites W4252769962 @default.
- W2068702958 doi "https://doi.org/10.1117/1.2709882" @default.
- W2068702958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17343478" @default.
- W2068702958 hasPublicationYear "2007" @default.
- W2068702958 type Work @default.
- W2068702958 sameAs 2068702958 @default.
- W2068702958 citedByCount "23" @default.
- W2068702958 countsByYear W20687029582013 @default.
- W2068702958 countsByYear W20687029582014 @default.
- W2068702958 countsByYear W20687029582015 @default.
- W2068702958 countsByYear W20687029582016 @default.
- W2068702958 countsByYear W20687029582017 @default.
- W2068702958 countsByYear W20687029582018 @default.
- W2068702958 countsByYear W20687029582019 @default.
- W2068702958 countsByYear W20687029582021 @default.
- W2068702958 countsByYear W20687029582022 @default.
- W2068702958 crossrefType "journal-article" @default.
- W2068702958 hasAuthorship W2068702958A5009351880 @default.
- W2068702958 hasAuthorship W2068702958A5041948925 @default.
- W2068702958 hasAuthorship W2068702958A5073832291 @default.
- W2068702958 hasBestOaLocation W20687029581 @default.
- W2068702958 hasConcept C105795698 @default.
- W2068702958 hasConcept C120456961 @default.
- W2068702958 hasConcept C120665830 @default.
- W2068702958 hasConcept C121332964 @default.
- W2068702958 hasConcept C125287762 @default.
- W2068702958 hasConcept C136229726 @default.
- W2068702958 hasConcept C178790620 @default.
- W2068702958 hasConcept C184050105 @default.
- W2068702958 hasConcept C185592680 @default.
- W2068702958 hasConcept C191486275 @default.
- W2068702958 hasConcept C192562407 @default.
- W2068702958 hasConcept C193493375 @default.
- W2068702958 hasConcept C19499675 @default.
- W2068702958 hasConcept C22078206 @default.
- W2068702958 hasConcept C2778227246 @default.
- W2068702958 hasConcept C2781323092 @default.
- W2068702958 hasConcept C33923547 @default.
- W2068702958 hasConcept C41999313 @default.
- W2068702958 hasConcept C502942594 @default.
- W2068702958 hasConcept C520434653 @default.
- W2068702958 hasConcept C69357855 @default.
- W2068702958 hasConcept C71924100 @default.
- W2068702958 hasConcept C97355855 @default.
- W2068702958 hasConceptScore W2068702958C105795698 @default.
- W2068702958 hasConceptScore W2068702958C120456961 @default.
- W2068702958 hasConceptScore W2068702958C120665830 @default.
- W2068702958 hasConceptScore W2068702958C121332964 @default.
- W2068702958 hasConceptScore W2068702958C125287762 @default.