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• W2068703393 abstract "Background: Para ‐phenylenediamine (PPD) and related chemicals are common contact sensitizers, frequently causing allergic contact dermatitis (ACD). The cytokine tumor necrosis factor‐alpha (TNF‐α) plays a key role in contact sensitization. Methods: In this case–control study, we evaluated the distribution of variations in the regulatory region of the gene for TNF‐α ( TNFA‐308 G/A ) in 181 Caucasian individuals with a history of ACD and sensitization to PPD and 161 individuals with no history of sensitization to PPD. Results: The frequency of GA or AA TNFA genotypes was significantly higher in individuals sensitized to PPD than in age‐ and gender‐matched controls giving an odds ratio (OR) of 2.16 (95% confidence interval, CI: 1.35–3.47; P = 0.0016). This relation was even more pronounced when restricting cases to females over 45 years (OR = 3.71; 95% CI: 1.65–8.31; P = 0.0017) vs younger females (less than or equal to 45 years; OR = 2.41; 95% CI: 1.03–5.65; P = 0.044) or males (OR = 1.05; 95% CI: 0.449–2.47; P = 1.0). In addition, a logistic regression model revealed a significant effect for TNFA‐308 AA and AG vs GG genotype (point estimate = 2.152; 95% Wald CI: 1.332–3.477). Conclusions: These findings suggest a possible role for the TNFA‐308 genetic polymorphism as a susceptibility factor for chemically induced ACD." @default.
• W2068703393 created "2016-06-24" @default.
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• W2068703393 date "2009-01-21" @default.
• W2068703393 modified "2023-10-12" @default.
• W2068703393 title "Association between<i>TNFA-308 G/A</i>polymorphism and sensitization to<i>para-</i>phenylenediamine: a case-control study" @default.
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• W2068703393 doi "https://doi.org/10.1111/j.1398-9995.2008.01704.x" @default.
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