FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068706667> ?p ?o ?g. }

• W2068706667 endingPage "199" @default.
• W2068706667 startingPage "193" @default.
• W2068706667 abstract "Increased mortality from cardiovascular diseases has been reported in acromegaly. Our objective was to evaluate the impact of glucose tolerance abnormalities and/or systemic hypertension in further worsening the acromegalic cardiomyopathy. The study design was open transversal. The subjects studied were 130 consecutive naive acromegalic patients (74 women and 56 men; age, 17-80 yr). Interventricular septum (IST) and left ventricular (LV) posterior wall thickness (PWT), LV mass index (LVMi), maximal early to late diastolic flow velocity ratio (E/A), isovolumic relaxation time (IRT), and LV ejection fraction (EF) were measured by echocardiography. The results were analyzed in line with the presence of glucose tolerance abnormalities (normal in 60, impaired in 38, diabetes mellitus in 32) and the presence (in 46) or absence (in 84) of hypertension. Patients with impaired glucose tolerance and diabetes mellitus had significantly higher age (P = 0.01), and systolic (P = 0.01) and diastolic (P = 0.01) blood pressures and lower E/A (P = 0.01) and EF (P = 0.01) than those with normal glucose tolerance. Disease duration, circulating GH and insulin-like growth factor I (IGF-I) levels, IST, LVPWT, LVMi, and IRT were similar in the 3 groups. Normotensive patients had significantly lower age (P<0.001), LVPWT (P<0.001), IST (P = 0.003), LVMi (P<0.001), and IRT (P = 0.02) and significantly higher E/A (P<0.001) and EF (P<0.001) than hypertensive subjects. Disease duration, circulating GH, and IGF-I levels were similar in the 2 groups. Multiple regression analysis showed that systolic blood pressure was the strongest predictor of LVMi (P = 0.0004), followed by GH levels (P = 0.02), whereas diastolic blood pressure was the strongest predictor of LVEF reduction (P<0.0001), followed by glucose tolerance status (P = 0.02). Age was the strongest predictor of both E/A impairment (P<0.0001) and IRT (P = 0.01), followed by IGF-I levels (P = 0.02). Compared to patients with uncomplicated acromegaly, those with hypertension but without abnormalities of glucose tolerance had an increased prevalence of LV hypertrophy (75% vs. 37.2%) as well as of impaired diastolic (50% vs. 7.8%) and systolic function (18.7% vs. 3.9%), whereas patients with glucose tolerance abnormalities but without hypertension had only an increased prevalence of impaired diastolic (39.7%) and systolic function (31.7%). The subgroup of acromegalic patients suffering from hypertension and diabetes mellitus had the highest prevalence of LV hypertrophy (84.6%), diastolic filling abnormalities (69.2%), and impaired systolic function at rest (53.9%). A careful cardiac investigation should thus be performed in all acromegalic patients showing these complications." @default.
• W2068706667 created "2016-06-24" @default.
• W2068706667 creator A5003544129 @default.
• W2068706667 creator A5005040201 @default.
• W2068706667 creator A5009957681 @default.
• W2068706667 creator A5037100565 @default.
• W2068706667 creator A5043401504 @default.
• W2068706667 creator A5048037056 @default.
• W2068706667 creator A5060194682 @default.
• W2068706667 creator A5061577134 @default.
• W2068706667 creator A5075614878 @default.
• W2068706667 creator A5077499862 @default.
• W2068706667 date "2000-01-01" @default.
• W2068706667 modified "2023-10-16" @default.
• W2068706667 title "Systemic Hypertension and Impaired Glucose Tolerance Are Independently Correlated to the Severity of the Acromegalic Cardiomyopathy1" @default.
• W2068706667 cites W131449026 @default.
• W2068706667 cites W1963631192 @default.
• W2068706667 cites W1974568996 @default.
• W2068706667 cites W1984572394 @default.
• W2068706667 cites W1992000752 @default.
• W2068706667 cites W1995026946 @default.
• W2068706667 cites W2006565016 @default.
• W2068706667 cites W2017943982 @default.
• W2068706667 cites W2018786551 @default.
• W2068706667 cites W2025638584 @default.
• W2068706667 cites W2032327430 @default.
• W2068706667 cites W2039647866 @default.
• W2068706667 cites W2041299478 @default.
• W2068706667 cites W2043750439 @default.
• W2068706667 cites W2081420411 @default.
• W2068706667 cites W2084779214 @default.
• W2068706667 cites W2086169986 @default.
• W2068706667 cites W2090925390 @default.
• W2068706667 cites W2091364914 @default.
• W2068706667 cites W2096073058 @default.
• W2068706667 cites W2097386490 @default.
• W2068706667 cites W2100480253 @default.
• W2068706667 cites W2123444701 @default.
• W2068706667 cites W2130112440 @default.
• W2068706667 cites W2135902934 @default.
• W2068706667 cites W2140572454 @default.
• W2068706667 cites W2164303686 @default.
• W2068706667 cites W2176813399 @default.
• W2068706667 cites W2186146257 @default.
• W2068706667 cites W228119655 @default.
• W2068706667 cites W2402220914 @default.
• W2068706667 cites W2467667708 @default.
• W2068706667 doi "https://doi.org/10.1210/jcem.85.1.6318" @default.
• W2068706667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10634386" @default.
• W2068706667 hasPublicationYear "2000" @default.
• W2068706667 type Work @default.
• W2068706667 sameAs 2068706667 @default.
• W2068706667 citedByCount "78" @default.
• W2068706667 countsByYear W20687066672012 @default.
• W2068706667 countsByYear W20687066672013 @default.
• W2068706667 countsByYear W20687066672014 @default.
• W2068706667 countsByYear W20687066672015 @default.
• W2068706667 countsByYear W20687066672016 @default.
• W2068706667 countsByYear W20687066672017 @default.
• W2068706667 countsByYear W20687066672018 @default.
• W2068706667 countsByYear W20687066672019 @default.
• W2068706667 countsByYear W20687066672020 @default.
• W2068706667 countsByYear W20687066672021 @default.
• W2068706667 countsByYear W20687066672022 @default.
• W2068706667 countsByYear W20687066672023 @default.
• W2068706667 crossrefType "journal-article" @default.
• W2068706667 hasAuthorship W2068706667A5003544129 @default.
• W2068706667 hasAuthorship W2068706667A5005040201 @default.
• W2068706667 hasAuthorship W2068706667A5009957681 @default.
• W2068706667 hasAuthorship W2068706667A5037100565 @default.
• W2068706667 hasAuthorship W2068706667A5043401504 @default.
• W2068706667 hasAuthorship W2068706667A5048037056 @default.
• W2068706667 hasAuthorship W2068706667A5060194682 @default.
• W2068706667 hasAuthorship W2068706667A5061577134 @default.
• W2068706667 hasAuthorship W2068706667A5075614878 @default.
• W2068706667 hasAuthorship W2068706667A5077499862 @default.
• W2068706667 hasBestOaLocation W20687066671 @default.
• W2068706667 hasConcept C126322002 @default.
• W2068706667 hasConcept C134018914 @default.
• W2068706667 hasConcept C164705383 @default.
• W2068706667 hasConcept C2776553924 @default.
• W2068706667 hasConcept C2777180221 @default.
• W2068706667 hasConcept C2777433750 @default.
• W2068706667 hasConcept C2778198053 @default.
• W2068706667 hasConcept C2778797674 @default.
• W2068706667 hasConcept C2778921608 @default.
• W2068706667 hasConcept C2779740085 @default.
• W2068706667 hasConcept C2779868719 @default.
• W2068706667 hasConcept C2780346441 @default.
• W2068706667 hasConcept C2780609358 @default.
• W2068706667 hasConcept C2984496839 @default.
• W2068706667 hasConcept C555293320 @default.
• W2068706667 hasConcept C57900726 @default.
• W2068706667 hasConcept C71315377 @default.
• W2068706667 hasConcept C71924100 @default.
• W2068706667 hasConcept C78085059 @default.
• W2068706667 hasConcept C84393581 @default.
• W2068706667 hasConceptScore W2068706667C126322002 @default.

• next