FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068707948> ?p ?o ?g. }

• W2068707948 endingPage "20" @default.
• W2068707948 startingPage "17" @default.
• W2068707948 abstract "We report evidence for a contribution of tetrodotoxin-resistant sodium current (TTX-R INa) to prostaglandin E2 (PGE2)-induced hyperalgesia. Behavioral experiments were performed in rats chronically implanted with spinal cannulae. The study employed intrathecal administration of oligodeoxynucleotide (ODN) antisense to the recently cloned channel underlying TTX-R INa (PN3/SNS). The nociceptive flexion reflex was employed to determine changes in mechanical stimulus-induced paw-withdrawal threshold. Administration of antisense but not of sense or mismatch ODN, led to a decrease in PGE2-induced hyperalgesia. PGE2-induced hyperalgesia returned to normal 7 days after the last injection of antisense ODN. Antisense ODN selectively and significantly reduced TTX-R INa current density in cultured sensory neurons. Our observations support the hypothesis that modulation of TTX-R INa, present in peripheral terminals of primary afferent nociceptors, contributes, at least in part, to inflammatory hyperalgesia. Since TTX-R INa is found only in primary afferent nociceptors, our findings suggest TTX-R INa as a promising target for novel therapeutic interventions for the treatment of inflammatory pain." @default.
• W2068707948 created "2016-06-24" @default.
• W2068707948 creator A5009507330 @default.
• W2068707948 creator A5037181353 @default.
• W2068707948 creator A5070024717 @default.
• W2068707948 date "1998-10-01" @default.
• W2068707948 modified "2023-10-16" @default.
• W2068707948 title "A tetrodotoxin-resistant sodium current mediates inflammatory pain in the rat" @default.
• W2068707948 cites W1978939719 @default.
• W2068707948 cites W1990512833 @default.
• W2068707948 cites W2000702493 @default.
• W2068707948 cites W2004118285 @default.
• W2068707948 cites W2008574207 @default.
• W2068707948 cites W2013947622 @default.
• W2068707948 cites W2021478036 @default.
• W2068707948 cites W2024920602 @default.
• W2068707948 cites W2039275254 @default.
• W2068707948 cites W2040393757 @default.
• W2068707948 cites W2055435244 @default.
• W2068707948 cites W2079576606 @default.
• W2068707948 cites W2084741333 @default.
• W2068707948 cites W2091746433 @default.
• W2068707948 cites W2124939272 @default.
• W2068707948 cites W2143973040 @default.
• W2068707948 cites W2411133343 @default.
• W2068707948 doi "https://doi.org/10.1016/s0304-3940(98)00738-1" @default.
• W2068707948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9832206" @default.
• W2068707948 hasPublicationYear "1998" @default.
• W2068707948 type Work @default.
• W2068707948 sameAs 2068707948 @default.
• W2068707948 citedByCount "205" @default.
• W2068707948 countsByYear W20687079482012 @default.
• W2068707948 countsByYear W20687079482013 @default.
• W2068707948 countsByYear W20687079482014 @default.
• W2068707948 countsByYear W20687079482015 @default.
• W2068707948 countsByYear W20687079482016 @default.
• W2068707948 countsByYear W20687079482017 @default.
• W2068707948 countsByYear W20687079482018 @default.
• W2068707948 countsByYear W20687079482019 @default.
• W2068707948 countsByYear W20687079482020 @default.
• W2068707948 countsByYear W20687079482021 @default.
• W2068707948 countsByYear W20687079482022 @default.
• W2068707948 crossrefType "journal-article" @default.
• W2068707948 hasAuthorship W2068707948A5009507330 @default.
• W2068707948 hasAuthorship W2068707948A5037181353 @default.
• W2068707948 hasAuthorship W2068707948A5070024717 @default.
• W2068707948 hasBestOaLocation W20687079482 @default.
• W2068707948 hasConcept C126322002 @default.
• W2068707948 hasConcept C134018914 @default.
• W2068707948 hasConcept C15490471 @default.
• W2068707948 hasConcept C169760540 @default.
• W2068707948 hasConcept C170493617 @default.
• W2068707948 hasConcept C172659308 @default.
• W2068707948 hasConcept C178790620 @default.
• W2068707948 hasConcept C185592680 @default.
• W2068707948 hasConcept C2776741303 @default.
• W2068707948 hasConcept C2777956040 @default.
• W2068707948 hasConcept C2779245659 @default.
• W2068707948 hasConcept C42219234 @default.
• W2068707948 hasConcept C50952357 @default.
• W2068707948 hasConcept C537181965 @default.
• W2068707948 hasConcept C71924100 @default.
• W2068707948 hasConcept C86803240 @default.
• W2068707948 hasConcept C98274493 @default.
• W2068707948 hasConceptScore W2068707948C126322002 @default.
• W2068707948 hasConceptScore W2068707948C134018914 @default.
• W2068707948 hasConceptScore W2068707948C15490471 @default.
• W2068707948 hasConceptScore W2068707948C169760540 @default.
• W2068707948 hasConceptScore W2068707948C170493617 @default.
• W2068707948 hasConceptScore W2068707948C172659308 @default.
• W2068707948 hasConceptScore W2068707948C178790620 @default.
• W2068707948 hasConceptScore W2068707948C185592680 @default.
• W2068707948 hasConceptScore W2068707948C2776741303 @default.
• W2068707948 hasConceptScore W2068707948C2777956040 @default.
• W2068707948 hasConceptScore W2068707948C2779245659 @default.
• W2068707948 hasConceptScore W2068707948C42219234 @default.
• W2068707948 hasConceptScore W2068707948C50952357 @default.
• W2068707948 hasConceptScore W2068707948C537181965 @default.
• W2068707948 hasConceptScore W2068707948C71924100 @default.
• W2068707948 hasConceptScore W2068707948C86803240 @default.
• W2068707948 hasConceptScore W2068707948C98274493 @default.
• W2068707948 hasIssue "1" @default.
• W2068707948 hasLocation W20687079481 @default.
• W2068707948 hasLocation W20687079482 @default.
• W2068707948 hasLocation W20687079483 @default.
• W2068707948 hasOpenAccess W2068707948 @default.
• W2068707948 hasPrimaryLocation W20687079481 @default.
• W2068707948 hasRelatedWork W1971982994 @default.
• W2068707948 hasRelatedWork W2019345844 @default.
• W2068707948 hasRelatedWork W2025379423 @default.
• W2068707948 hasRelatedWork W2065806690 @default.
• W2068707948 hasRelatedWork W2068707948 @default.
• W2068707948 hasRelatedWork W2145540995 @default.
• W2068707948 hasRelatedWork W2178820168 @default.
• W2068707948 hasRelatedWork W2179850034 @default.
• W2068707948 hasRelatedWork W2353684536 @default.
• W2068707948 hasRelatedWork W3199808206 @default.
• W2068707948 hasVolume "256" @default.

• next