Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068708596> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2068708596 endingPage "926" @default.
- W2068708596 startingPage "919" @default.
- W2068708596 abstract "Objective: To determine the effect of induced hypothermia on bacterial growth, lung injury, and mitochondrial function in a rat model of pneumococcal pneumosepsis. Design: Animal study. Setting: University research laboratory. Subjects: Male Sprague-Dawley rats. Interventions: Subjects were inoculated intratracheally with Streptococcus pneumoniae and controls received saline. After the development of pneumonia, mechanical ventilation was started with or without induced mild hypothermia (32°C). Bacterial growth and inflammatory markers were determined in bronchoalveolar lavage fluid, blood, and organs. Oxidative phosphorylation and adenosine triphosphate contents were measured in mitochondria isolated from the liver and soleus muscle. Measurements and Main Results: Inoculation with S. pneumoniae resulted in severe pneumonia with bacterial dissemination, distal organ injury, and blunted peripheral oxygen consumption on mechanical ventilation. Hypothermia did not affect bacterial growth in bronchoalveolar lavage fluid and in homogenized lungs compared with normothermic controls but was associated with reduced bacterial dissemination to the spleen with a trend toward reduced bacterial load in blood and liver. Hypothermia reduced lung injury, exemplified by reductions in pulmonary cell influx and bronchoalveolar lavage fluid protein levels compared with controls. Hypothermia reduced bronchoalveolar lavage fluid levels of interleukin-1β, tended to reduce bronchoalveolar lavage fluid CINC-3 levels, but no effect was observed on bronchoalveolar lavage fluid tumor necrosis factor-α and interleukin-6 levels. Induced hypothermia restored the fall in oxygen consumption and adenosine triphosphate levels in the liver, whereas adenosine triphosphate/adenosine diphosphate ratios remained low. In muscle, induced hypothermia also reversed low oxygen consumption as a result of pneumonia, but with an increase in adenosine triphosphate levels, whereas adenosine triphosphate/adenosine diphosphate ratios were low. Conclusion: Hypothermia did not adversely affect bacterial growth, but rather reduced bacterial dissemination in a rat model of pneumococcal pneumosepsis. Furthermore, hypothermia reduced lung injury associated with restored adenosine triphosphate availability and turnover. These findings suggest that hypothermia may reduce organ injury by preventing sepsis-related mitochondrial dysfunction." @default.
- W2068708596 created "2016-06-24" @default.
- W2068708596 creator A5008601270 @default.
- W2068708596 creator A5013315693 @default.
- W2068708596 creator A5049024951 @default.
- W2068708596 creator A5062978034 @default.
- W2068708596 creator A5072840045 @default.
- W2068708596 creator A5080838480 @default.
- W2068708596 creator A5086646404 @default.
- W2068708596 creator A5087188370 @default.
- W2068708596 creator A5091785748 @default.
- W2068708596 date "2012-03-01" @default.
- W2068708596 modified "2023-10-15" @default.
- W2068708596 title "Induced hypothermia is protective in a rat model of pneumococcal pneumonia associated with increased adenosine triphosphate availability and turnover*" @default.
- W2068708596 cites W1965361671 @default.
- W2068708596 cites W2091798965 @default.
- W2068708596 cites W2113649272 @default.
- W2068708596 cites W2113691221 @default.
- W2068708596 cites W2116422254 @default.
- W2068708596 cites W2121462621 @default.
- W2068708596 cites W2155937122 @default.
- W2068708596 cites W2334231168 @default.
- W2068708596 doi "https://doi.org/10.1097/ccm.0b013e3182373174" @default.
- W2068708596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22036856" @default.
- W2068708596 hasPublicationYear "2012" @default.
- W2068708596 type Work @default.
- W2068708596 sameAs 2068708596 @default.
- W2068708596 citedByCount "26" @default.
- W2068708596 countsByYear W20687085962012 @default.
- W2068708596 countsByYear W20687085962013 @default.
- W2068708596 countsByYear W20687085962014 @default.
- W2068708596 countsByYear W20687085962015 @default.
- W2068708596 countsByYear W20687085962016 @default.
- W2068708596 countsByYear W20687085962017 @default.
- W2068708596 countsByYear W20687085962018 @default.
- W2068708596 countsByYear W20687085962019 @default.
- W2068708596 countsByYear W20687085962020 @default.
- W2068708596 countsByYear W20687085962023 @default.
- W2068708596 crossrefType "journal-article" @default.
- W2068708596 hasAuthorship W2068708596A5008601270 @default.
- W2068708596 hasAuthorship W2068708596A5013315693 @default.
- W2068708596 hasAuthorship W2068708596A5049024951 @default.
- W2068708596 hasAuthorship W2068708596A5062978034 @default.
- W2068708596 hasAuthorship W2068708596A5072840045 @default.
- W2068708596 hasAuthorship W2068708596A5080838480 @default.
- W2068708596 hasAuthorship W2068708596A5086646404 @default.
- W2068708596 hasAuthorship W2068708596A5087188370 @default.
- W2068708596 hasAuthorship W2068708596A5091785748 @default.
- W2068708596 hasConcept C126322002 @default.
- W2068708596 hasConcept C203014093 @default.
- W2068708596 hasConcept C2777390192 @default.
- W2068708596 hasConcept C2777714996 @default.
- W2068708596 hasConcept C2777961210 @default.
- W2068708596 hasConcept C2779564974 @default.
- W2068708596 hasConcept C2779892413 @default.
- W2068708596 hasConcept C2781253189 @default.
- W2068708596 hasConcept C501593827 @default.
- W2068708596 hasConcept C71924100 @default.
- W2068708596 hasConcept C86803240 @default.
- W2068708596 hasConcept C89423630 @default.
- W2068708596 hasConceptScore W2068708596C126322002 @default.
- W2068708596 hasConceptScore W2068708596C203014093 @default.
- W2068708596 hasConceptScore W2068708596C2777390192 @default.
- W2068708596 hasConceptScore W2068708596C2777714996 @default.
- W2068708596 hasConceptScore W2068708596C2777961210 @default.
- W2068708596 hasConceptScore W2068708596C2779564974 @default.
- W2068708596 hasConceptScore W2068708596C2779892413 @default.
- W2068708596 hasConceptScore W2068708596C2781253189 @default.
- W2068708596 hasConceptScore W2068708596C501593827 @default.
- W2068708596 hasConceptScore W2068708596C71924100 @default.
- W2068708596 hasConceptScore W2068708596C86803240 @default.
- W2068708596 hasConceptScore W2068708596C89423630 @default.
- W2068708596 hasIssue "3" @default.
- W2068708596 hasLocation W20687085961 @default.
- W2068708596 hasLocation W20687085962 @default.
- W2068708596 hasOpenAccess W2068708596 @default.
- W2068708596 hasPrimaryLocation W20687085961 @default.
- W2068708596 hasRelatedWork W1556863319 @default.
- W2068708596 hasRelatedWork W1601412208 @default.
- W2068708596 hasRelatedWork W1905511256 @default.
- W2068708596 hasRelatedWork W2008697807 @default.
- W2068708596 hasRelatedWork W2104353241 @default.
- W2068708596 hasRelatedWork W2131543814 @default.
- W2068708596 hasRelatedWork W2134186248 @default.
- W2068708596 hasRelatedWork W2419183136 @default.
- W2068708596 hasRelatedWork W2525759404 @default.
- W2068708596 hasRelatedWork W2955469462 @default.
- W2068708596 hasVolume "40" @default.
- W2068708596 isParatext "false" @default.
- W2068708596 isRetracted "false" @default.
- W2068708596 magId "2068708596" @default.
- W2068708596 workType "article" @default.