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- W2068709547 abstract "1. The release of [3H]dopamine from isolated presynaptic nerve terminals (synaptosomes) prepared from rat striata was measured as a function of the external Ca2+ concentration ([Ca2+]o). 2. In synaptosomes depolarized by the addition of 50 mM-K+, release of [3H]dopamine increased in a highly non-linear manner with [Ca2+]o. The release could be described as a third power function of [Ca2+]o. 3. Both 45Ca2+ influx and the change in the free cytosolic Ca2+ concentration ([Ca2+]i, measured with the fluorescent Ca2+ indicator fura-2) that were evoked by depolarization increased in a linear manner with [Ca2+]o. 4. These results suggest that non-linearity in the [Ca2+]o dependence of transmitter release originates in a co-operative relation between [Ca2+]i and exocytosis." @default.
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- W2068709547 date "1987-06-01" @default.
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- W2068709547 title "Co-operative action of calcium ions in dopamine release from rat brain synaptosomes." @default.
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- W2068709547 doi "https://doi.org/10.1113/jphysiol.1987.sp016581" @default.
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