Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068709920> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2068709920 endingPage "56" @default.
- W2068709920 startingPage "52" @default.
- W2068709920 abstract "The purpose of this study was to compare liver contrast-enhancing characteristics of two superparamagnetic reticuloendothelial system (RES)-directed agents with different particle sizes, polycrystalline iron oxide nanocompounds (PION) and carboxydextran-coated maghemite (DDM128N/389, later referred to as DDM128), in an experimental model of focal radiation-induced hepatitis. PION, for the small particle size (31 nm), and DDM128, for the large particle size (59 nm), RES-directed agents were compared for liver enhancement after radiation-induced liver injury. A single x-irradiation exposure varying from 10 to 60 Gy was delivered to one side of the liver. T2-weighted spinecho magnetic resonance imaging was performed 3 days after x-irradiation at 30 minutes post-contrast. Using the RES-directed PION, the normal, non-irradiated portion of the liver decreased in signal intensity with a maximum negative enhancement of -66%, while the irradiated portion of the liver decreased in signal intensity by -24% (60 Gy). The signal intensity decline of irradiated liver tissue using PION was dose dependent, but was found at all radiation dose levels (10-60 Gy). The difference in signal intensity between irradiated (-63%) and non-irradiated (-82%) portions was also statistically different using DDM128 at 60 Gy. However, lower irradiation doses (10 and 30 Gy) failed to produce a statistically significantly different enhancement in the irradiated and non-irradiated portion of the liver. Sensitivity of liver enhancement with RES-directed agents is size dependent. The smaller particle (PION) is more sensitive for detection of radiation-induced hepatitis than the larger particle (DDM128). The relative insensitivity of DDM128 enhancement for diffuse liver injury will be clinically advantageous for detecting focal lesions in the presence of diffuse hepatic injury." @default.
- W2068709920 created "2016-06-24" @default.
- W2068709920 creator A5003167945 @default.
- W2068709920 creator A5023941388 @default.
- W2068709920 creator A5036873605 @default.
- W2068709920 creator A5041895846 @default.
- W2068709920 creator A5044411862 @default.
- W2068709920 creator A5056632696 @default.
- W2068709920 creator A5061236362 @default.
- W2068709920 creator A5077215695 @default.
- W2068709920 date "1999-07-01" @default.
- W2068709920 modified "2023-09-26" @default.
- W2068709920 title "Contrast-enhanced MR imaging of two superparamagnetic RES-contrast agents: Functional assessment of experimental radiation-induced liver injury" @default.
- W2068709920 cites W1965951866 @default.
- W2068709920 cites W1972582749 @default.
- W2068709920 cites W1978435125 @default.
- W2068709920 cites W2055685464 @default.
- W2068709920 cites W2067511268 @default.
- W2068709920 cites W2071125913 @default.
- W2068709920 cites W2071971662 @default.
- W2068709920 cites W2077387095 @default.
- W2068709920 cites W2110118058 @default.
- W2068709920 cites W2126561846 @default.
- W2068709920 cites W2142566766 @default.
- W2068709920 cites W2149874407 @default.
- W2068709920 cites W2151231035 @default.
- W2068709920 cites W2154620120 @default.
- W2068709920 cites W2160988717 @default.
- W2068709920 cites W2165627216 @default.
- W2068709920 cites W2168371215 @default.
- W2068709920 doi "https://doi.org/10.1002/(sici)1522-2586(199907)10:1<52::aid-jmri7>3.0.co;2-c" @default.
- W2068709920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10398977" @default.
- W2068709920 hasPublicationYear "1999" @default.
- W2068709920 type Work @default.
- W2068709920 sameAs 2068709920 @default.
- W2068709920 citedByCount "7" @default.
- W2068709920 countsByYear W20687099202015 @default.
- W2068709920 countsByYear W20687099202020 @default.
- W2068709920 crossrefType "journal-article" @default.
- W2068709920 hasAuthorship W2068709920A5003167945 @default.
- W2068709920 hasAuthorship W2068709920A5023941388 @default.
- W2068709920 hasAuthorship W2068709920A5036873605 @default.
- W2068709920 hasAuthorship W2068709920A5041895846 @default.
- W2068709920 hasAuthorship W2068709920A5044411862 @default.
- W2068709920 hasAuthorship W2068709920A5056632696 @default.
- W2068709920 hasAuthorship W2068709920A5061236362 @default.
- W2068709920 hasAuthorship W2068709920A5077215695 @default.
- W2068709920 hasBestOaLocation W20687099201 @default.
- W2068709920 hasConcept C111337013 @default.
- W2068709920 hasConcept C121332964 @default.
- W2068709920 hasConcept C126322002 @default.
- W2068709920 hasConcept C126838900 @default.
- W2068709920 hasConcept C142724271 @default.
- W2068709920 hasConcept C143409427 @default.
- W2068709920 hasConcept C185544564 @default.
- W2068709920 hasConcept C192562407 @default.
- W2068709920 hasConcept C19702531 @default.
- W2068709920 hasConcept C2776637226 @default.
- W2068709920 hasConcept C2989005 @default.
- W2068709920 hasConcept C46141821 @default.
- W2068709920 hasConcept C71924100 @default.
- W2068709920 hasConceptScore W2068709920C111337013 @default.
- W2068709920 hasConceptScore W2068709920C121332964 @default.
- W2068709920 hasConceptScore W2068709920C126322002 @default.
- W2068709920 hasConceptScore W2068709920C126838900 @default.
- W2068709920 hasConceptScore W2068709920C142724271 @default.
- W2068709920 hasConceptScore W2068709920C143409427 @default.
- W2068709920 hasConceptScore W2068709920C185544564 @default.
- W2068709920 hasConceptScore W2068709920C192562407 @default.
- W2068709920 hasConceptScore W2068709920C19702531 @default.
- W2068709920 hasConceptScore W2068709920C2776637226 @default.
- W2068709920 hasConceptScore W2068709920C2989005 @default.
- W2068709920 hasConceptScore W2068709920C46141821 @default.
- W2068709920 hasConceptScore W2068709920C71924100 @default.
- W2068709920 hasIssue "1" @default.
- W2068709920 hasLocation W20687099201 @default.
- W2068709920 hasLocation W20687099202 @default.
- W2068709920 hasOpenAccess W2068709920 @default.
- W2068709920 hasPrimaryLocation W20687099201 @default.
- W2068709920 hasRelatedWork W2004879827 @default.
- W2068709920 hasRelatedWork W2036317449 @default.
- W2068709920 hasRelatedWork W2045749492 @default.
- W2068709920 hasRelatedWork W2050080970 @default.
- W2068709920 hasRelatedWork W2354901326 @default.
- W2068709920 hasRelatedWork W2356139802 @default.
- W2068709920 hasRelatedWork W2356956512 @default.
- W2068709920 hasRelatedWork W2473431470 @default.
- W2068709920 hasRelatedWork W2899084033 @default.
- W2068709920 hasRelatedWork W3176325444 @default.
- W2068709920 hasVolume "10" @default.
- W2068709920 isParatext "false" @default.
- W2068709920 isRetracted "false" @default.
- W2068709920 magId "2068709920" @default.
- W2068709920 workType "article" @default.