FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068710106> ?p ?o ?g. }

• W2068710106 endingPage "791" @default.
• W2068710106 startingPage "782" @default.
• W2068710106 abstract "Studies were carried out to compare the effects of parathyroid extract (PTE) on serum and urinary calcium (Ca) and phosphorus (P), serum 25-hydroxyvitamin D (25-OHD), serum 24,25-dihydroxyvitamin D (24,25(OH)2D), serum 1 alpha,25-dihydroxyvitamin D (1 alpha,25(OH)2D), and urinary cyclic AMP in two normal subjects, two patients with hypoparathyroidism (HP) and six patients with pseudohypoparathyroidism (PHP), some of whom were on suboptimal treatment with vitamin D. Two of the patients with PHP were studied while on long-term treatment with 1 alpha,25-(OH)2D3. Before PTE, serum 1 alpha, 25(OH)2D was at the lower limit of normal in one patient and was abnormally low in the other five patients. None of these individuals was on treatment with 1 alpha,25(OH)2D3. Serum 25-OHD and 24,25(OH)2D were either increased or at the upper limit of normal in the patients given vitamin D and were normal in the other patients. PTE lowered the serum P and increased the serum 1 alpha,25(OH)2D, serum and urinary Ca, urinary P, and urinary cyclic AMP in the normal subjects and patients with HP. In individual studies, changes in serum 1 alpha,25(OH)2D and serum Ca occurred in parallel before, during, and after PTE. In contrast, PTE had very little effect in the patients with PHP. Whereas there were highly significant positive correlations between serum 1 alpha,25(OH)2D in each of the normal subjects and patients with HP, there were significant correlations in only one of the patients with PHP. An increase in serum Ca in response to PTE was observed in one of the two patients with PHP who were on long-term treatment with 1 alpha,25(OH)2D3. In these individuals, PTE produced only slight increases in serum 1 alpha,25(OH)2D. Serum 25-OHD and 24,25(OH)2D were not changed by PTE in any of the subjects or patients. The results provide evidence that hypocalcemia in HP and PHP arises in part from low circulating 1 alpha,25-(OH)2D, and indicate that the lack of change in serum 1 alpha,25(OH)2D with PTE in patients with PHP is related to impaired renal adenylate cyclase and phosphaturic responses. These and previous results support the idea that diminished renal production of 1 alpha,25(OH)2D, because of a defect in the parathyroid hormone-responsive adenylate cyclase system, may be a contributing factor in the pathogenesis of the abnormal calcium metabolism in PHP." @default.
• W2068710106 created "2016-06-24" @default.
• W2068710106 creator A5002462495 @default.
• W2068710106 creator A5008601445 @default.
• W2068710106 creator A5037882841 @default.
• W2068710106 creator A5048222389 @default.
• W2068710106 date "1980-10-01" @default.
• W2068710106 modified "2023-10-18" @default.
• W2068710106 title "Demonstration of a lack of change in serum 1 alpha,25-dihydroxyvitamin D in response to parathyroid extract in pseudohypoparathyroidism." @default.
• W2068710106 cites W1602972606 @default.
• W2068710106 cites W1622682983 @default.
• W2068710106 cites W1907394035 @default.
• W2068710106 cites W1970268355 @default.
• W2068710106 cites W1970394371 @default.
• W2068710106 cites W1970896143 @default.
• W2068710106 cites W1986803862 @default.
• W2068710106 cites W1992214240 @default.
• W2068710106 cites W1992927694 @default.
• W2068710106 cites W1993964514 @default.
• W2068710106 cites W1996466550 @default.
• W2068710106 cites W1997993870 @default.
• W2068710106 cites W1999936179 @default.
• W2068710106 cites W2006984526 @default.
• W2068710106 cites W2008916694 @default.
• W2068710106 cites W2018682732 @default.
• W2068710106 cites W2022456040 @default.
• W2068710106 cites W2022909845 @default.
• W2068710106 cites W2027289047 @default.
• W2068710106 cites W2027554623 @default.
• W2068710106 cites W2034686025 @default.
• W2068710106 cites W2040398774 @default.
• W2068710106 cites W2041711947 @default.
• W2068710106 cites W2056406453 @default.
• W2068710106 cites W2057343936 @default.
• W2068710106 cites W2066841262 @default.
• W2068710106 cites W2068626362 @default.
• W2068710106 cites W2069076309 @default.
• W2068710106 cites W2082080634 @default.
• W2068710106 cites W2085061302 @default.
• W2068710106 cites W2092033046 @default.
• W2068710106 cites W2125291250 @default.
• W2068710106 cites W2138217697 @default.
• W2068710106 cites W2148028431 @default.
• W2068710106 cites W2204049599 @default.
• W2068710106 cites W2280737718 @default.
• W2068710106 cites W2332207559 @default.
• W2068710106 cites W2341814959 @default.
• W2068710106 cites W2397797875 @default.
• W2068710106 cites W2414719779 @default.
• W2068710106 cites W2415811542 @default.
• W2068710106 doi "https://doi.org/10.1172/jci109916" @default.
• W2068710106 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/371653" @default.
• W2068710106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7419719" @default.
• W2068710106 hasPublicationYear "1980" @default.
• W2068710106 type Work @default.
• W2068710106 sameAs 2068710106 @default.
• W2068710106 citedByCount "65" @default.
• W2068710106 countsByYear W20687101062015 @default.
• W2068710106 countsByYear W20687101062020 @default.
• W2068710106 crossrefType "journal-article" @default.
• W2068710106 hasAuthorship W2068710106A5002462495 @default.
• W2068710106 hasAuthorship W2068710106A5008601445 @default.
• W2068710106 hasAuthorship W2068710106A5037882841 @default.
• W2068710106 hasAuthorship W2068710106A5048222389 @default.
• W2068710106 hasBestOaLocation W20687101061 @default.
• W2068710106 hasConcept C124490489 @default.
• W2068710106 hasConcept C126322002 @default.
• W2068710106 hasConcept C134018914 @default.
• W2068710106 hasConcept C141071460 @default.
• W2068710106 hasConcept C185592680 @default.
• W2068710106 hasConcept C2775941721 @default.
• W2068710106 hasConcept C2775944032 @default.
• W2068710106 hasConcept C2780356894 @default.
• W2068710106 hasConcept C2781208988 @default.
• W2068710106 hasConcept C49453240 @default.
• W2068710106 hasConcept C519063684 @default.
• W2068710106 hasConcept C64943373 @default.
• W2068710106 hasConcept C71924100 @default.
• W2068710106 hasConcept C77411442 @default.
• W2068710106 hasConceptScore W2068710106C124490489 @default.
• W2068710106 hasConceptScore W2068710106C126322002 @default.
• W2068710106 hasConceptScore W2068710106C134018914 @default.
• W2068710106 hasConceptScore W2068710106C141071460 @default.
• W2068710106 hasConceptScore W2068710106C185592680 @default.
• W2068710106 hasConceptScore W2068710106C2775941721 @default.
• W2068710106 hasConceptScore W2068710106C2775944032 @default.
• W2068710106 hasConceptScore W2068710106C2780356894 @default.
• W2068710106 hasConceptScore W2068710106C2781208988 @default.
• W2068710106 hasConceptScore W2068710106C49453240 @default.
• W2068710106 hasConceptScore W2068710106C519063684 @default.
• W2068710106 hasConceptScore W2068710106C64943373 @default.
• W2068710106 hasConceptScore W2068710106C71924100 @default.
• W2068710106 hasConceptScore W2068710106C77411442 @default.
• W2068710106 hasIssue "4" @default.
• W2068710106 hasLocation W20687101061 @default.
• W2068710106 hasLocation W20687101062 @default.
• W2068710106 hasLocation W20687101063 @default.
• W2068710106 hasLocation W20687101064 @default.

• next