FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068711204> ?p ?o ?g. }

• W2068711204 endingPage "120" @default.
• W2068711204 startingPage "112" @default.
• W2068711204 abstract "The mouse serves as a valuable model for treatment leading to the prevention and therapy of inner ear disease. Transgenic correction of genetic inner ear disease in mice may help develop treatment for human genetic inner ear disease. In mutations involving hair cells (HCs) or supporting cells (SCs), it is necessary to insert the wild-type transgenes directly into these cells. We used inner ear explants to characterize the transgenic expression using adenovirus-mediated reporter genes (bacterial lacZ). The variable parameters were the age of the explants (P1–P5), the type of vector (first and advanced generation adenovirus) and the genotype of the mouse (wild-type versus shaker-2 mutant). Transduction of cochlear HCs was detected at P1 and in some of the P3 cochleae. Low efficiency transduction of SCs was observed in P1 explants, but the efficiency increased with age and reached high levels at P5. The pattern of transduction was similar regardless of the genotype and the type of vector used. The data demonstrate that differentiating HCs and SCs in mouse explants can be transduced by adenovirus vectors, suggesting that cultures of mouse ears are a valuable model for developing inner ear gene therapy protocols." @default.
• W2068711204 created "2016-06-24" @default.
• W2068711204 creator A5001201586 @default.
• W2068711204 creator A5020938661 @default.
• W2068711204 creator A5021824059 @default.
• W2068711204 creator A5054057203 @default.
• W2068711204 date "2002-07-01" @default.
• W2068711204 modified "2023-10-17" @default.
• W2068711204 title "Transgene expression in neonatal mouse inner ear explants mediated by first and advanced generation adenovirus vectors" @default.
• W2068711204 cites W1588831374 @default.
• W2068711204 cites W1681143022 @default.
• W2068711204 cites W1972648569 @default.
• W2068711204 cites W1974875111 @default.
• W2068711204 cites W1975949784 @default.
• W2068711204 cites W1982511534 @default.
• W2068711204 cites W2007761110 @default.
• W2068711204 cites W2012484552 @default.
• W2068711204 cites W2018218006 @default.
• W2068711204 cites W2025740124 @default.
• W2068711204 cites W2034636386 @default.
• W2068711204 cites W2038772880 @default.
• W2068711204 cites W2041179764 @default.
• W2068711204 cites W2050117643 @default.
• W2068711204 cites W2056618065 @default.
• W2068711204 cites W2067986718 @default.
• W2068711204 cites W2073765832 @default.
• W2068711204 cites W2077647167 @default.
• W2068711204 cites W2107658807 @default.
• W2068711204 cites W2109043842 @default.
• W2068711204 cites W2110680416 @default.
• W2068711204 cites W2113257602 @default.
• W2068711204 cites W2130986890 @default.
• W2068711204 cites W2131434998 @default.
• W2068711204 cites W2140423552 @default.
• W2068711204 cites W2142178277 @default.
• W2068711204 cites W2142626694 @default.
• W2068711204 cites W2146845216 @default.
• W2068711204 cites W2163643581 @default.
• W2068711204 cites W2315109968 @default.
• W2068711204 cites W2334644780 @default.
• W2068711204 cites W4236558674 @default.
• W2068711204 cites W4241564980 @default.
• W2068711204 cites W4254709174 @default.
• W2068711204 doi "https://doi.org/10.1016/s0378-5955(02)00347-7" @default.
• W2068711204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12121744" @default.
• W2068711204 hasPublicationYear "2002" @default.
• W2068711204 type Work @default.
• W2068711204 sameAs 2068711204 @default.
• W2068711204 citedByCount "20" @default.
• W2068711204 countsByYear W20687112042012 @default.
• W2068711204 countsByYear W20687112042014 @default.
• W2068711204 countsByYear W20687112042015 @default.
• W2068711204 countsByYear W20687112042016 @default.
• W2068711204 countsByYear W20687112042018 @default.
• W2068711204 countsByYear W20687112042022 @default.
• W2068711204 crossrefType "journal-article" @default.
• W2068711204 hasAuthorship W2068711204A5001201586 @default.
• W2068711204 hasAuthorship W2068711204A5020938661 @default.
• W2068711204 hasAuthorship W2068711204A5021824059 @default.
• W2068711204 hasAuthorship W2068711204A5054057203 @default.
• W2068711204 hasConcept C102230213 @default.
• W2068711204 hasConcept C104317684 @default.
• W2068711204 hasConcept C105702510 @default.
• W2068711204 hasConcept C111599444 @default.
• W2068711204 hasConcept C141035611 @default.
• W2068711204 hasConcept C143065580 @default.
• W2068711204 hasConcept C150194340 @default.
• W2068711204 hasConcept C15152581 @default.
• W2068711204 hasConcept C153911025 @default.
• W2068711204 hasConcept C157890192 @default.
• W2068711204 hasConcept C161733203 @default.
• W2068711204 hasConcept C202751555 @default.
• W2068711204 hasConcept C207583985 @default.
• W2068711204 hasConcept C2776954459 @default.
• W2068711204 hasConcept C2778500370 @default.
• W2068711204 hasConcept C2780130748 @default.
• W2068711204 hasConcept C32470452 @default.
• W2068711204 hasConcept C40767141 @default.
• W2068711204 hasConcept C54355233 @default.
• W2068711204 hasConcept C55493867 @default.
• W2068711204 hasConcept C86803240 @default.
• W2068711204 hasConcept C95444343 @default.
• W2068711204 hasConceptScore W2068711204C102230213 @default.
• W2068711204 hasConceptScore W2068711204C104317684 @default.
• W2068711204 hasConceptScore W2068711204C105702510 @default.
• W2068711204 hasConceptScore W2068711204C111599444 @default.
• W2068711204 hasConceptScore W2068711204C141035611 @default.
• W2068711204 hasConceptScore W2068711204C143065580 @default.
• W2068711204 hasConceptScore W2068711204C150194340 @default.
• W2068711204 hasConceptScore W2068711204C15152581 @default.
• W2068711204 hasConceptScore W2068711204C153911025 @default.
• W2068711204 hasConceptScore W2068711204C157890192 @default.
• W2068711204 hasConceptScore W2068711204C161733203 @default.
• W2068711204 hasConceptScore W2068711204C202751555 @default.
• W2068711204 hasConceptScore W2068711204C207583985 @default.
• W2068711204 hasConceptScore W2068711204C2776954459 @default.
• W2068711204 hasConceptScore W2068711204C2778500370 @default.
• W2068711204 hasConceptScore W2068711204C2780130748 @default.

• next