FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068711229> ?p ?o ?g. }

• W2068711229 endingPage "262" @default.
• W2068711229 startingPage "249" @default.
• W2068711229 abstract "The sparse grid-based experiment design algorithm sequentially selects an experimental design point to discriminate between hypotheses for given experimental conditions. Sparse grids efficiently screen the global uncertain parameter space to identify acceptable parameter subspaces. Clustering the located acceptable parameter vectors by the similarity of the simulated model trajectories characterises the data-compatible model dynamics. The experiment design algorithm capitalises on the diversity of the experimentally distinguishable system output dynamics to select the design point that best discerns between competing model-structure and parameter-encoded hypotheses. As opposed to designing the experiments to explicitly reduce uncertainty in the model parameters, this approach selects design points to differentiate between dynamical behaviours. This approach further differs from other experimental design methods in that it simultaneously addresses both parameter- and structural-based uncertainty that is applicable to some ill-posed problems where the number of uncertain parameters exceeds the amount of data, places very few requirements on the model type, available data and a priori parameter estimates, and is performed over the global uncertain parameter space. The experiment design algorithm is demonstrated on a mitogen-activated protein kinase cascade model. The results show that system dynamics are highly uncertain with limited experimental data. Nevertheless, the algorithm requires only three additional experimental data points to simultaneously discriminate between possible model structures and acceptable parameter values. This sparse grid-based experiment design process provides a systematic and computationally efficient exploration over the entire uncertain parameter space of potential model structures to resolve the uncertainty in the non-linear systems biology model dynamics." @default.
• W2068711229 created "2016-06-24" @default.
• W2068711229 creator A5020010248 @default.
• W2068711229 creator A5048545593 @default.
• W2068711229 creator A5049933939 @default.
• W2068711229 date "2010-07-01" @default.
• W2068711229 modified "2023-10-16" @default.
• W2068711229 title "Experiment design through dynamical characterisation of non-linear systems biology models utilising sparse grids" @default.
• W2068711229 cites W1586497728 @default.
• W2068711229 cites W1968238080 @default.
• W2068711229 cites W1976422597 @default.
• W2068711229 cites W1992066335 @default.
• W2068711229 cites W2002763634 @default.
• W2068711229 cites W2012985604 @default.
• W2068711229 cites W2036284542 @default.
• W2068711229 cites W2058821377 @default.
• W2068711229 cites W2075692822 @default.
• W2068711229 cites W2081629343 @default.
• W2068711229 cites W2088102099 @default.
• W2068711229 cites W2091105822 @default.
• W2068711229 cites W2094537558 @default.
• W2068711229 cites W2096450322 @default.
• W2068711229 cites W2124293649 @default.
• W2068711229 cites W2124630954 @default.
• W2068711229 cites W2161891455 @default.
• W2068711229 cites W4241793634 @default.
• W2068711229 cites W4376453181 @default.
• W2068711229 cites W77750393 @default.
• W2068711229 doi "https://doi.org/10.1049/iet-syb.2009.0031" @default.
• W2068711229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20632775" @default.
• W2068711229 hasPublicationYear "2010" @default.
• W2068711229 type Work @default.
• W2068711229 sameAs 2068711229 @default.
• W2068711229 citedByCount "20" @default.
• W2068711229 countsByYear W20687112292012 @default.
• W2068711229 countsByYear W20687112292013 @default.
• W2068711229 countsByYear W20687112292014 @default.
• W2068711229 countsByYear W20687112292015 @default.
• W2068711229 countsByYear W20687112292016 @default.
• W2068711229 countsByYear W20687112292017 @default.
• W2068711229 countsByYear W20687112292019 @default.
• W2068711229 crossrefType "journal-article" @default.
• W2068711229 hasAuthorship W2068711229A5020010248 @default.
• W2068711229 hasAuthorship W2068711229A5048545593 @default.
• W2068711229 hasAuthorship W2068711229A5049933939 @default.
• W2068711229 hasConcept C105795698 @default.
• W2068711229 hasConcept C111472728 @default.
• W2068711229 hasConcept C11413529 @default.
• W2068711229 hasConcept C121332964 @default.
• W2068711229 hasConcept C12362212 @default.
• W2068711229 hasConcept C126255220 @default.
• W2068711229 hasConcept C138885662 @default.
• W2068711229 hasConcept C154945302 @default.
• W2068711229 hasConcept C167928553 @default.
• W2068711229 hasConcept C187691185 @default.
• W2068711229 hasConcept C2524010 @default.
• W2068711229 hasConcept C33923547 @default.
• W2068711229 hasConcept C34559072 @default.
• W2068711229 hasConcept C41008148 @default.
• W2068711229 hasConcept C55037315 @default.
• W2068711229 hasConcept C62520636 @default.
• W2068711229 hasConcept C73555534 @default.
• W2068711229 hasConcept C73586568 @default.
• W2068711229 hasConcept C75553542 @default.
• W2068711229 hasConcept C79379906 @default.
• W2068711229 hasConceptScore W2068711229C105795698 @default.
• W2068711229 hasConceptScore W2068711229C111472728 @default.
• W2068711229 hasConceptScore W2068711229C11413529 @default.
• W2068711229 hasConceptScore W2068711229C121332964 @default.
• W2068711229 hasConceptScore W2068711229C12362212 @default.
• W2068711229 hasConceptScore W2068711229C126255220 @default.
• W2068711229 hasConceptScore W2068711229C138885662 @default.
• W2068711229 hasConceptScore W2068711229C154945302 @default.
• W2068711229 hasConceptScore W2068711229C167928553 @default.
• W2068711229 hasConceptScore W2068711229C187691185 @default.
• W2068711229 hasConceptScore W2068711229C2524010 @default.
• W2068711229 hasConceptScore W2068711229C33923547 @default.
• W2068711229 hasConceptScore W2068711229C34559072 @default.
• W2068711229 hasConceptScore W2068711229C41008148 @default.
• W2068711229 hasConceptScore W2068711229C55037315 @default.
• W2068711229 hasConceptScore W2068711229C62520636 @default.
• W2068711229 hasConceptScore W2068711229C73555534 @default.
• W2068711229 hasConceptScore W2068711229C73586568 @default.
• W2068711229 hasConceptScore W2068711229C75553542 @default.
• W2068711229 hasConceptScore W2068711229C79379906 @default.
• W2068711229 hasIssue "4" @default.
• W2068711229 hasLocation W20687112291 @default.
• W2068711229 hasLocation W20687112292 @default.
• W2068711229 hasOpenAccess W2068711229 @default.
• W2068711229 hasPrimaryLocation W20687112291 @default.
• W2068711229 hasRelatedWork W1562204561 @default.
• W2068711229 hasRelatedWork W1963542395 @default.
• W2068711229 hasRelatedWork W2016085465 @default.
• W2068711229 hasRelatedWork W2022297208 @default.
• W2068711229 hasRelatedWork W2036048170 @default.
• W2068711229 hasRelatedWork W2068711229 @default.
• W2068711229 hasRelatedWork W2269908781 @default.
• W2068711229 hasRelatedWork W2888702978 @default.

• next