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- W2068711270 abstract "We planned to ascertain whether the administration of the anticholinesterase, tacrine (5 mg/kg i.p.), to rats pretreated 24 h before with lithium chloride (LiCl; 12 mEq/kg i.p.) produced any change in nitric oxide (NO) synthase activity in the hippocampus. A significant increase in hippocampal Ca2+-calmodulin-dependent NO synthase activity occurred 15 min after tacrine injection and was blocked by atropine (5 mg/kg i.p. given 15 min before tacrine) and by Nω-nitro-L-arginine methyl ester (300 μg given into one lateral cerebral ventricle 10 min before tacrine), a NO synthase inhibitor. A consistent cyclic guanosine 3′,5′-monophosphate (cGMP) accumulation was also seen. In conclusion, the present results show that tacrine given to LiCl-pretreated rats produces a significant increase in NO synthase activity in the hippocampus and this may be responsible, at least in part, for seizures and related brain damage elicited by these drugs." @default.
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- W2068711270 date "1993-06-01" @default.
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- W2068711270 title "Systemic administration of lithium chloride and tacrine increases nitric oxide synthase activity in the hippocampus of rats" @default.
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- W2068711270 doi "https://doi.org/10.1016/0014-2999(93)90093-w" @default.
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