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- W2068722437 abstract "The development of sensitive reagents and detection systems, together with the introduction of heat-induced antigen retrieval, has rapidly entrenched immunohistology as an indispensable adjunct to routine histological examination, contributing to diagnosis, prognosis and treatment. New antibodies continue to be produced and new applications for old antibodies are described. The production of antibodies enabling the detection of genetic abnormalities, including mutations, gene amplifications and specific chromosomal translocations associated with novel chimeric proteins, promises to yield further insights into the genesis and behaviour of tumours. The ability to stain for target molecules that regulate tumour growth and proliferation is essential for selecting tumours for treatment with monoclonal antibodies. The mechanism of antigen retrieval remains debated. The absence of optimal controls continues to hinder standardisation of immunostaining and invalidates current attempts at quantification of immunostaining." @default.
- W2068722437 created "2016-06-24" @default.
- W2068722437 creator A5033385387 @default.
- W2068722437 creator A5046047089 @default.
- W2068722437 date "2006-05-05" @default.
- W2068722437 modified "2023-10-18" @default.
- W2068722437 title "Newer developments in immunohistology" @default.
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- W2068722437 doi "https://doi.org/10.1136/jcp.2005.031179" @default.
- W2068722437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1860504" @default.
- W2068722437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17071800" @default.
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