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- W2068731031 abstract "Endogeneous and exogeneous amine-containing substances possess pneumophilic properties. Among them, tricyclic amphiphilic amine drugs like neuroleptics intensively accumulate in the lung cell membrane and occasionally cause severe respiratory disorders. In the present study, we examined the bioelectric toxicity of chlorpromazine (CPZ), a commonly used neuroleptic, in human lung epithelial cells. CPZ concentration-dependently inhibited the isoproterenol (ISO)-generated short-circuit current (Isc) sensitive to a nonselective K+ channel blocker, clotrimazole (30 μM), but insensitive to a selective Ca2+-activated K+ (KCa) channel blocker, charybdotoxin (ChTx, 100 nM). The effects of apical CPZ on the ISO-induced responses were greater than those of basolateral CPZ. Forskolin- and 8-bromo-cyclic AMP-induced Isc were partially prevented by CPZ. Nystatin permeabilization of the monolayers revealed that CPZ attenuated the basolateral K+ current elicited by ISO more than that elicited by forskolin and that the apical Cl− current elicited by forskolin was instead potentiated by CPZ, although it inhibited the ISO-induced Cl− current. 1-Ethyl-2-benzimdazolinone (1-EBIO, a KCa channel opener, 500 μM)- and ionomycin (Ca2+ ionophore, 1 μM)-evoked Cl− secretions were also sensitive to CPZ. These results indicate that CPZ inhibits transepithelial Cl− transport, affecting at least two different targets: the β-adrenergic receptor and the basolateral K+ channels (especially the KCa channel). Electrostatic interactions at the inner surface of the membrane between the protonated amines of CPZ and negatively charged portions of the plasma membrane may be involved in the mechanisms." @default.
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- W2068731031 date "2002-09-01" @default.
- W2068731031 modified "2023-09-27" @default.
- W2068731031 title "Bioelectric Toxicity Caused by Chlorpromazine in Human Lung Epithelial Cells" @default.
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- W2068731031 doi "https://doi.org/10.1006/taap.2002.9486" @default.
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