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- W2068732348 abstract "To explore the impact of Alzheimer's disease amyloid β protein (Aβ) on astrocyte functions, we investigated the effect of Aβ on glutamate clearance capacity of cultured rat cortical astrocytes. When l-glutamate (50–200 μM) was added to astrocyte cultures and incubated, the extracellular l-glutamate concentration declined with time. The time-dependent decline of extracellular l-glutamate was significantly faster in cultures treated with 10–20 μM Aβ for 24 h than in intact cultures, suggesting that Aβ enhances the l-glutamate clearance capacity of astrocytes. The effect of Aβ was not affected by antioxidants including catalase, propyl gallate or Trolox. Relatively long treatment time (8–48 h) was required for Aβ to exert this effect. Western blot analysis revealed that expression level of the glutamate transporter GLAST was increased by treatment with 10–20 μM Aβ for 8–48 h. These results suggest that Aβ? upregulates a glutamate uptake system of astrocytes and enhances the clearance of extracellular l-glutamate." @default.
- W2068732348 created "2016-06-24" @default.
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- W2068732348 date "2003-01-01" @default.
- W2068732348 modified "2023-09-23" @default.
- W2068732348 title "Amyloid β protein enhances the clearance of extracellular l-glutamate by cultured rat cortical astrocytes" @default.
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- W2068732348 doi "https://doi.org/10.1016/s0168-0102(02)00190-6" @default.
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