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• W2068741131 endingPage "645" @default.
• W2068741131 startingPage "639" @default.
• W2068741131 abstract "The major limitation of Doxorubicin (Dox) clinical use is the development of chronic and acute toxic side effects induced through the generation of reactive oxygen species. The present work was designated to investigate in vitro effects of a red grape-seed hydroethanolic extract Burgund Mare (BM), in associated administration with Dox (30 min before drug administration) in normal (Hfl-1) and tumor cell lines (HepG2 and Mls). The BM concentrations administered were below the level of the extract cytotoxiciy threshold (40 μg gallic acid [GA] Eq/mL; 37.5, 25.0, and 12.5 μg GA Eq/mL). The antioxidant capacity of the BM extract was assessed by measuring the acute toxicity at 24 h, lipid peroxides (LP), and protein oxidation. In normal cells, the product statistically decreased cytotoxicity and markedly inhibited LP and protein carbonyl (PC) formation, in a dose-dependent relationship. On contrary, in tumor cells, such treatment resulted in a reversed effect, cell death, malondialdehyde, and PC contents increasing with BM dose enhancement. BM extract treatment prior to subsequent administration of Dox afforded a differential protection against Dox-negative toxic side effects in normal cells without weakening (even enhancing) Dox's antitumor activity." @default.
• W2068741131 created "2016-06-24" @default.
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• W2068741131 date "2012-07-01" @default.
• W2068741131 modified "2023-10-17" @default.
• W2068741131 title "Modulation of Doxorubicin-Induced Oxidative Stress by a Grape (<i>Vitis vinifera</i>L.) Seed Extract in Normal and Tumor Cells" @default.
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• W2068741131 doi "https://doi.org/10.1089/jmf.2011.0291" @default.
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• W2068741131 hasPublicationYear "2012" @default.
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