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• W2068741585 abstract "The accuracy of metabolic quantification in MR spectroscopy is limited by the unknown radiofrequency field and T1. To address both issues in proton (1H) MR spectroscopy, we obtained radiofrequency field–corrected T1 maps of N-acetylaspartate, choline, and creatine in five healthy rhesus macaques at 3 T. For efficient use of the 4 hour experiment, we used a new three-point protocol that optimizes the precision of T1 in three-dimensional 1H-MR spectroscopy localization for extensive, ∼30%, brain coverage at 0.6 × 0.6 × 0.5 cm3 = 180-μL spatial resolution. The resulting mean T1s in 700 voxels were N-acetylaspartate = 1232 ± 44, creatine = 1238 ± 23 and choline = 1107 ± 56 ms (mean ± standard error of the mean). Their histograms from all 140 voxels in each animal were similar in position and shape, characterized by standard errors of the mean of the full width at half maximum divided by their means of better than 8%. Regional gray matter N-acetylaspartate, choline, and creatine T1s (1333 ± 43, 1265 ± 52, and 1131 ± 28 ms) were 5–10% longer than white matter: 1188 ± 34, 1201 ± 24, and 1082 ± 50 ms (statistically significant for the N-acetylaspartate only), all within 10% of the corresponding published values in the human brain. Magn Reson Med 63:865–871, 2010. © 2010 Wiley-Liss, Inc." @default.
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• W2068741585 date "2010-05-01" @default.
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• W2068741585 title "Brain metabolites<i>B</i>₁-corrected proton<i>T</i>₁mapping in the rhesus macaque at 3 T" @default.
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• W2068741585 doi "https://doi.org/10.1002/mrm.22270" @default.
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