FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068742213> ?p ?o ?g. }

• W2068742213 endingPage "966" @default.
• W2068742213 startingPage "956" @default.
• W2068742213 abstract "Pituitary adenylate cyclase-activating polypeptide (PACAP) has been reported to increase intracellular Ca2+ concentrations ([Ca2+]i) and catecholamine release in adrenal chromaffin cells. We measured [Ca2+]i with fura-2 and recorded ion currents and membrane potentials with the whole cell configuration of the patch-clamp technique to elucidate the mechanism of PACAP-induced [Ca2+]i increase in bovine adrenal chromaffin cells. PACAP caused [Ca2+]i to increase due to Ca2+ release and Ca2+ influx, and this was accompanied by membrane depolarization and inward currents. The Ca2+ release was suppressed by ryanodine, an inhibitor of caffeine-sensitive Ca2+ stores, but was unaffected by cinnarizine, an inhibitor of inositol trisphosphate-induced Ca2+ release. Ca2+ influx and inward currents were both inhibited by replacement of extracellular Na+, and Ca2+ influx was inhibited by nicardipine, an L-type Ca2+ channel blocker, or by staurosporine, a protein kinase C (PKC) inhibitor, but was unaffected by a combination of omega- conotoxin-GVIA, omega-agatoxin-IVA, and omega-conotoxin- MVIIC, blockers of N-, P-, and Q-type Ca2+ channels. Moreover, 1-oleoyl-2-acetyl-sn-glycerol, a PKC activator, induced inward currents and Ca2+ influx. These results indicate that PACAP causes both Ca2+ release, mainly from caffeine-sensitive Ca2+ stores, and Ca2+ influx via L-type Ca2+ channels activated by membrane depolarization that depends on PKC-mediated Na+ influx." @default.
• W2068742213 created "2016-06-24" @default.
• W2068742213 creator A5048008812 @default.
• W2068742213 creator A5050010393 @default.
• W2068742213 creator A5067085986 @default.
• W2068742213 creator A5068345284 @default.
• W2068742213 creator A5085816166 @default.
• W2068742213 date "1996-03-01" @default.
• W2068742213 modified "2023-10-14" @default.
• W2068742213 title "Pituitary adenylate cyclase-activating polypeptide causes rapid Ca2+ release from intracellular stores and long lasting Ca2+ influx mediated by Na+ influx-dependent membrane depolarization in bovine adrenal chromaffin cells." @default.
• W2068742213 cites W1531815379 @default.
• W2068742213 cites W1547329911 @default.
• W2068742213 cites W1964383390 @default.
• W2068742213 cites W1965772541 @default.
• W2068742213 cites W1966886300 @default.
• W2068742213 cites W1969614286 @default.
• W2068742213 cites W1969630044 @default.
• W2068742213 cites W1969949852 @default.
• W2068742213 cites W1973923561 @default.
• W2068742213 cites W1979067492 @default.
• W2068742213 cites W1981423842 @default.
• W2068742213 cites W1985262137 @default.
• W2068742213 cites W1988510192 @default.
• W2068742213 cites W1995226061 @default.
• W2068742213 cites W2001439970 @default.
• W2068742213 cites W2002615780 @default.
• W2068742213 cites W2003318594 @default.
• W2068742213 cites W2004855020 @default.
• W2068742213 cites W2007169332 @default.
• W2068742213 cites W2017351296 @default.
• W2068742213 cites W2019655661 @default.
• W2068742213 cites W2028677429 @default.
• W2068742213 cites W2033650768 @default.
• W2068742213 cites W2047523044 @default.
• W2068742213 cites W2056112038 @default.
• W2068742213 cites W2057906214 @default.
• W2068742213 cites W2066399601 @default.
• W2068742213 cites W2068617048 @default.
• W2068742213 cites W2070078411 @default.
• W2068742213 cites W2090966569 @default.
• W2068742213 cites W2094407013 @default.
• W2068742213 cites W2096977013 @default.
• W2068742213 cites W2103153455 @default.
• W2068742213 cites W2129137786 @default.
• W2068742213 cites W2141260882 @default.
• W2068742213 cites W2161021458 @default.
• W2068742213 cites W2171652062 @default.
• W2068742213 cites W2280695533 @default.
• W2068742213 cites W2399155185 @default.
• W2068742213 cites W2416512630 @default.
• W2068742213 doi "https://doi.org/10.1210/endo.137.3.8603609" @default.
• W2068742213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8603609" @default.
• W2068742213 hasPublicationYear "1996" @default.
• W2068742213 type Work @default.
• W2068742213 sameAs 2068742213 @default.
• W2068742213 citedByCount "58" @default.
• W2068742213 countsByYear W20687422132012 @default.
• W2068742213 countsByYear W20687422132013 @default.
• W2068742213 countsByYear W20687422132017 @default.
• W2068742213 countsByYear W20687422132018 @default.
• W2068742213 countsByYear W20687422132020 @default.
• W2068742213 countsByYear W20687422132021 @default.
• W2068742213 countsByYear W20687422132022 @default.
• W2068742213 crossrefType "journal-article" @default.
• W2068742213 hasAuthorship W2068742213A5048008812 @default.
• W2068742213 hasAuthorship W2068742213A5050010393 @default.
• W2068742213 hasAuthorship W2068742213A5067085986 @default.
• W2068742213 hasAuthorship W2068742213A5068345284 @default.
• W2068742213 hasAuthorship W2068742213A5085816166 @default.
• W2068742213 hasBestOaLocation W20687422131 @default.
• W2068742213 hasConcept C11960822 @default.
• W2068742213 hasConcept C12554922 @default.
• W2068742213 hasConcept C126322002 @default.
• W2068742213 hasConcept C134018914 @default.
• W2068742213 hasConcept C153461711 @default.
• W2068742213 hasConcept C185592680 @default.
• W2068742213 hasConcept C195794163 @default.
• W2068742213 hasConcept C2775894120 @default.
• W2068742213 hasConcept C2777597313 @default.
• W2068742213 hasConcept C2780910648 @default.
• W2068742213 hasConcept C4141045 @default.
• W2068742213 hasConcept C519063684 @default.
• W2068742213 hasConcept C55493867 @default.
• W2068742213 hasConcept C71924100 @default.
• W2068742213 hasConcept C86803240 @default.
• W2068742213 hasConceptScore W2068742213C11960822 @default.
• W2068742213 hasConceptScore W2068742213C12554922 @default.
• W2068742213 hasConceptScore W2068742213C126322002 @default.
• W2068742213 hasConceptScore W2068742213C134018914 @default.
• W2068742213 hasConceptScore W2068742213C153461711 @default.
• W2068742213 hasConceptScore W2068742213C185592680 @default.
• W2068742213 hasConceptScore W2068742213C195794163 @default.
• W2068742213 hasConceptScore W2068742213C2775894120 @default.
• W2068742213 hasConceptScore W2068742213C2777597313 @default.
• W2068742213 hasConceptScore W2068742213C2780910648 @default.
• W2068742213 hasConceptScore W2068742213C4141045 @default.
• W2068742213 hasConceptScore W2068742213C519063684 @default.
• W2068742213 hasConceptScore W2068742213C55493867 @default.

• next