Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068743334> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2068743334 endingPage "8800" @default.
- W2068743334 startingPage "8794" @default.
- W2068743334 abstract "A solution-state NMR study on 15NH4+ ion movement within d(G3T4G4)2, a dimeric G-quadruplex consisting of three G-quartets and two T4 loops, rather unexpectedly demonstrated the absence of 15NH4+ ion movement between the binding sites U and L along the central axis of the G-quadruplex. Distinct temperature dependences of autocorrelation signals for U and L binding sites have been observed in 15N−1H NzExHSQC spectra which correlate with the local stiffness of the G-quadruplex. The volumes of the cross-peaks, which are the result of 15NH4+ ion movement, have been interpreted in terms of rate constants, T1 relaxation, and proton exchange. 15NH4+ ion movements from the binding sites U and L into the bulk solution are characterized by lifetimes of 139 ms and 1.7 s at 298 K, respectively. The 12 times faster movement from the binding site U demonstrates that 15NH4+ ion movement is controlled by the structure of T4 loop residues, which through diagonal- vs edge-type orientations impose distinct steric restraints for cations to leave or enter the G-quadruplex. Arrhenius-type analysis has afforded an activation energy of 66 kJ mol-1 for the UB process, while it could not be determined for the LB process due to slow rates at temperatures below 298 K. We further the use of the 15NH4+ ion as an NMR probe to gain insight into the occupancy of binding sites by cations and kinetics of ion movement which are intrinsically correlated with the structural details, dynamic fluctuations, and local flexibility of the DNA structure." @default.
- W2068743334 created "2016-06-24" @default.
- W2068743334 creator A5048391694 @default.
- W2068743334 creator A5065487450 @default.
- W2068743334 date "2007-06-20" @default.
- W2068743334 modified "2023-10-01" @default.
- W2068743334 title "Not All G-Quadruplexes Exhibit Ion-Channel-like Properties: NMR Study of Ammonium Ion (Non)movement within the d(G<sub>3</sub>T<sub>4</sub>G<sub>4</sub>)<sub>2</sub> Quadruplex" @default.
- W2068743334 cites W1964208165 @default.
- W2068743334 cites W1968179613 @default.
- W2068743334 cites W1979115564 @default.
- W2068743334 cites W1983023891 @default.
- W2068743334 cites W1986648841 @default.
- W2068743334 cites W1996497565 @default.
- W2068743334 cites W1997586605 @default.
- W2068743334 cites W2006092704 @default.
- W2068743334 cites W2008120871 @default.
- W2068743334 cites W2009215313 @default.
- W2068743334 cites W2011844193 @default.
- W2068743334 cites W2023129490 @default.
- W2068743334 cites W2027439553 @default.
- W2068743334 cites W2028609152 @default.
- W2068743334 cites W2036400318 @default.
- W2068743334 cites W2061902828 @default.
- W2068743334 cites W2073669518 @default.
- W2068743334 cites W2091065275 @default.
- W2068743334 cites W2120721020 @default.
- W2068743334 cites W2132306213 @default.
- W2068743334 cites W2157596926 @default.
- W2068743334 cites W2169745877 @default.
- W2068743334 cites W2171830519 @default.
- W2068743334 doi "https://doi.org/10.1021/ja0710003" @default.
- W2068743334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17580943" @default.
- W2068743334 hasPublicationYear "2007" @default.
- W2068743334 type Work @default.
- W2068743334 sameAs 2068743334 @default.
- W2068743334 citedByCount "32" @default.
- W2068743334 countsByYear W20687433342012 @default.
- W2068743334 countsByYear W20687433342013 @default.
- W2068743334 countsByYear W20687433342014 @default.
- W2068743334 countsByYear W20687433342015 @default.
- W2068743334 countsByYear W20687433342016 @default.
- W2068743334 countsByYear W20687433342017 @default.
- W2068743334 countsByYear W20687433342018 @default.
- W2068743334 countsByYear W20687433342019 @default.
- W2068743334 countsByYear W20687433342021 @default.
- W2068743334 countsByYear W20687433342023 @default.
- W2068743334 crossrefType "journal-article" @default.
- W2068743334 hasAuthorship W2068743334A5048391694 @default.
- W2068743334 hasAuthorship W2068743334A5065487450 @default.
- W2068743334 hasConcept C103319777 @default.
- W2068743334 hasConcept C113196181 @default.
- W2068743334 hasConcept C145148216 @default.
- W2068743334 hasConcept C178790620 @default.
- W2068743334 hasConcept C185592680 @default.
- W2068743334 hasConcept C201194858 @default.
- W2068743334 hasConcept C2779870022 @default.
- W2068743334 hasConcept C71240020 @default.
- W2068743334 hasConcept C8010536 @default.
- W2068743334 hasConceptScore W2068743334C103319777 @default.
- W2068743334 hasConceptScore W2068743334C113196181 @default.
- W2068743334 hasConceptScore W2068743334C145148216 @default.
- W2068743334 hasConceptScore W2068743334C178790620 @default.
- W2068743334 hasConceptScore W2068743334C185592680 @default.
- W2068743334 hasConceptScore W2068743334C201194858 @default.
- W2068743334 hasConceptScore W2068743334C2779870022 @default.
- W2068743334 hasConceptScore W2068743334C71240020 @default.
- W2068743334 hasConceptScore W2068743334C8010536 @default.
- W2068743334 hasIssue "28" @default.
- W2068743334 hasLocation W20687433341 @default.
- W2068743334 hasLocation W20687433342 @default.
- W2068743334 hasOpenAccess W2068743334 @default.
- W2068743334 hasPrimaryLocation W20687433341 @default.
- W2068743334 hasRelatedWork W2012602682 @default.
- W2068743334 hasRelatedWork W2065862411 @default.
- W2068743334 hasRelatedWork W2071055611 @default.
- W2068743334 hasRelatedWork W2102293398 @default.
- W2068743334 hasRelatedWork W2344209642 @default.
- W2068743334 hasRelatedWork W2952015118 @default.
- W2068743334 hasRelatedWork W3200462162 @default.
- W2068743334 hasRelatedWork W4280608521 @default.
- W2068743334 hasRelatedWork W2463810949 @default.
- W2068743334 hasRelatedWork W2470468744 @default.
- W2068743334 hasVolume "129" @default.
- W2068743334 isParatext "false" @default.
- W2068743334 isRetracted "false" @default.
- W2068743334 magId "2068743334" @default.
- W2068743334 workType "article" @default.