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• W2068746444 abstract "Helper T lymphocytes play a critical role in immune system activation following recognition of MHC class II-bound peptide ligands (pMHCII). These CD4 T cells stimulate B cell antibody production and cytolytic T cell generation. Until recently, the structural basis of coordinate T cell receptor (TCR) and CD4 co-receptor interaction with a given pMHCII was unknown. Here we review current structural data on specific pMHCII recognition by T cells and compare TCR and co-receptor docking to pMHCI versus pMHCII ligands. The implications of these findings for thymic selection, helper versus cytolytic T cell recognition and alloreactivity are discussed." @default.
• W2068746444 created "2016-06-24" @default.
• W2068746444 creator A5006030795 @default.
• W2068746444 creator A5013709830 @default.
• W2068746444 date "2002-05-01" @default.
• W2068746444 modified "2023-10-13" @default.
• W2068746444 title "Structural basis of T cell recognition of peptides bound to MHC molecules" @default.
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• W2068746444 doi "https://doi.org/10.1016/s0161-5890(02)00033-0" @default.
• W2068746444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11955596" @default.
• W2068746444 hasPublicationYear "2002" @default.
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