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• W2068746521 endingPage "474" @default.
• W2068746521 startingPage "463" @default.
• W2068746521 abstract "Metastatic dissemination to the oral cavity is rare and is usually the evidence of a wide spread disease with an average survival rate of 7 months. In almost a quarter of the cases, oral metastasis was found to be the first indication of an occult malignancy at a distant site. Metastatic lesions can be found anywhere in the oral cavity, however, the jawbones with the molar area is the most frequently involved site. In the oral soft tissues, the gingiva is the most common site, suggesting the possible role of inflammation in the attraction of metastatic deposits. The most common primary malignancies presenting oral metastases were the lung, kidney, liver, and prostate for men, and breast, female genital organs, kidney, and colo-rectum for women. Most patients with jawbone metastasis complain of swelling, pain, and paresthesia. An exophytic lesion is the most common clinical presentation of metastatic lesions in the oral soft tissues. Early lesions, mainly those located in the gingiva, may resemble a hyperplastic or reactive lesion. Once a lesion is recognized as metastasis, the primary tumor site should be identified following clinical, radiological and histopathological investigations. If standardized diagnostic workup fails to detect the site of origin, then the term carcinoma of unknown primary is applied. Personalized medicine tools such as tissue-of-origin assays should be applied, either by immunohistochemical testing or by molecular-profiling methods as these may lead to a more favorable outcome." @default.
• W2068746521 created "2016-06-24" @default.
• W2068746521 creator A5002777386 @default.
• W2068746521 creator A5054329810 @default.
• W2068746521 creator A5059146427 @default.
• W2068746521 creator A5062199973 @default.
• W2068746521 date "2014-11-20" @default.
• W2068746521 modified "2023-10-15" @default.
• W2068746521 title "Metastatic Tumors to the Jaws and Mouth" @default.
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• W2068746521 doi "https://doi.org/10.1007/s12105-014-0591-z" @default.

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