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- W2068746675 abstract "Early detection of focal hepatic lesions is a challenge in clinical routine and becomes even greater in the presence of a diffuse parenchymal disease. This study aimed to evaluate the diagnostic performance of contrast-enhanced ultrasonography (CEUS) and elastography for early detection of malignant hepatic nodules in an experimental rat model (LIMA et al., 2008) of non-alcoholic steatohepatitis (NASH). CEUS and elastography were performed in ten normal adult Sprague-Dawley rats (control group). B-mode and Doppler ultrasonography were performed weekly in ten experimental rats with focal liver lesions. Then, they underwent elastography and CEUS, sacrifice and assessment by microscopy. Tissue stiffness of the nodules on elastography were classified in negative (elastic strain) or positive (hard and no strain) comparing with surrounding liver parenchyma. In the early phase, wash in was significantly associated with malignancy (sensitivity of 71% and specificity of 100%). Also wash out, in the late phase was associated with malignancy (sensitivity of 86% and specificity of 67%). Elastograms of positive lesions showed areaa of high shear stiffness, which were indicative of malignancy confirmed on histology evaluation, with sensitivity of 100% and specificity of 90%. Both techniques allow making right diagnosis with high accuracy in an experimental rat model of NASH. Elastography provided promising perspectives for the assessment of malignancy of focal hepatic lesions." @default.
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- W2068746675 date "2011-08-01" @default.
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- W2068746675 title "Contrast-Enhanced Ultrasonography and Elastography of Focal Lesions in an Experimental Model of Hepatocellular Carcinoma" @default.
- W2068746675 doi "https://doi.org/10.1016/j.ultrasmedbio.2011.05.108" @default.
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