FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068750071> ?p ?o ?g. }

• W2068750071 endingPage "27146" @default.
• W2068750071 startingPage "27139" @default.
• W2068750071 abstract "HMG-CoA reductase (HMGR) catalyzes a rate-limiting step in sterol biosynthesis and is a key control point in the feedback inhibition that regulates this pathway. Through the action of the membrane protein Insig, HMGR synthesis and degradation are regulated to maintain sterol homeostasis. The fission yeast Schizosaccharomyces pombe encodes homologs of HMGR and Insig called hmg1(+) and ins1(+), respectively. In contrast to the mammalian system, Ins1 regulates Hmg1 by a nondegradative mechanism involving phosphorylation of the Hmg1 active site. Here, we investigate the role of the Ins1-Hmg1 system in coupling glucose sensing to regulation of sterol biosynthesis. We show that Ins1-dependent Hmg1 phosphorylation is strongly induced in response to glucose withdrawal and that HMGR activity is correspondingly reduced. We also find that inability to activate Hmg1 phosphorylation under nutrient limiting conditions results in overaccumulation of sterol pathway intermediates. Furthermore, we show that regulation of Hmg1 phosphorylation requires the protein phosphatase 2A-related phosphatase Ppe1 and its regulator Sds23. These results describe a mechanism by which cells tune the rate of sterol synthesis to match nutrient availability." @default.
• W2068750071 created "2016-06-24" @default.
• W2068750071 creator A5008400892 @default.
• W2068750071 creator A5023176439 @default.
• W2068750071 date "2011-08-01" @default.
• W2068750071 modified "2023-09-26" @default.
• W2068750071 title "Glucose Controls Phosphoregulation of Hydroxymethylglutaryl Coenzyme A Reductase through the Protein Phosphatase 2A-related Phosphatase Protein, Ppe1, and Insig in Fission Yeast" @default.
• W2068750071 cites W1497350129 @default.
• W2068750071 cites W1949031059 @default.
• W2068750071 cites W1965204294 @default.
• W2068750071 cites W1969913401 @default.
• W2068750071 cites W1974600093 @default.
• W2068750071 cites W1990265320 @default.
• W2068750071 cites W1997761763 @default.
• W2068750071 cites W2000233707 @default.
• W2068750071 cites W2004408400 @default.
• W2068750071 cites W2030266364 @default.
• W2068750071 cites W2041745300 @default.
• W2068750071 cites W2050403522 @default.
• W2068750071 cites W2071124826 @default.
• W2068750071 cites W2091098948 @default.
• W2068750071 cites W2092312719 @default.
• W2068750071 cites W2112822852 @default.
• W2068750071 cites W2114825009 @default.
• W2068750071 cites W2115420718 @default.
• W2068750071 cites W2118029488 @default.
• W2068750071 cites W2124036862 @default.
• W2068750071 cites W2126268158 @default.
• W2068750071 cites W2131115981 @default.
• W2068750071 cites W2147672037 @default.
• W2068750071 cites W2153101930 @default.
• W2068750071 cites W2158645874 @default.
• W2068750071 cites W2164035034 @default.
• W2068750071 cites W2166714586 @default.
• W2068750071 cites W2170716497 @default.
• W2068750071 cites W2178198123 @default.
• W2068750071 doi "https://doi.org/10.1074/jbc.m111.233452" @default.
• W2068750071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3149307" @default.
• W2068750071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21680738" @default.
• W2068750071 hasPublicationYear "2011" @default.
• W2068750071 type Work @default.
• W2068750071 sameAs 2068750071 @default.
• W2068750071 citedByCount "7" @default.
• W2068750071 countsByYear W20687500712012 @default.
• W2068750071 countsByYear W20687500712014 @default.
• W2068750071 countsByYear W20687500712017 @default.
• W2068750071 countsByYear W20687500712020 @default.
• W2068750071 countsByYear W20687500712021 @default.
• W2068750071 crossrefType "journal-article" @default.
• W2068750071 hasAuthorship W2068750071A5008400892 @default.
• W2068750071 hasAuthorship W2068750071A5023176439 @default.
• W2068750071 hasBestOaLocation W20687500711 @default.
• W2068750071 hasConcept C11960822 @default.
• W2068750071 hasConcept C134651460 @default.
• W2068750071 hasConcept C178666793 @default.
• W2068750071 hasConcept C181199279 @default.
• W2068750071 hasConcept C185592680 @default.
• W2068750071 hasConcept C2777576037 @default.
• W2068750071 hasConcept C2778163477 @default.
• W2068750071 hasConcept C2778718757 @default.
• W2068750071 hasConcept C2779222958 @default.
• W2068750071 hasConcept C2779429346 @default.
• W2068750071 hasConcept C55493867 @default.
• W2068750071 hasConcept C86803240 @default.
• W2068750071 hasConcept C95444343 @default.
• W2068750071 hasConceptScore W2068750071C11960822 @default.
• W2068750071 hasConceptScore W2068750071C134651460 @default.
• W2068750071 hasConceptScore W2068750071C178666793 @default.
• W2068750071 hasConceptScore W2068750071C181199279 @default.
• W2068750071 hasConceptScore W2068750071C185592680 @default.
• W2068750071 hasConceptScore W2068750071C2777576037 @default.
• W2068750071 hasConceptScore W2068750071C2778163477 @default.
• W2068750071 hasConceptScore W2068750071C2778718757 @default.
• W2068750071 hasConceptScore W2068750071C2779222958 @default.
• W2068750071 hasConceptScore W2068750071C2779429346 @default.
• W2068750071 hasConceptScore W2068750071C55493867 @default.
• W2068750071 hasConceptScore W2068750071C86803240 @default.
• W2068750071 hasConceptScore W2068750071C95444343 @default.
• W2068750071 hasIssue "31" @default.
• W2068750071 hasLocation W20687500711 @default.
• W2068750071 hasLocation W20687500712 @default.
• W2068750071 hasLocation W20687500713 @default.
• W2068750071 hasLocation W20687500714 @default.
• W2068750071 hasOpenAccess W2068750071 @default.
• W2068750071 hasPrimaryLocation W20687500711 @default.
• W2068750071 hasRelatedWork W1662173082 @default.
• W2068750071 hasRelatedWork W1996019871 @default.
• W2068750071 hasRelatedWork W1999771206 @default.
• W2068750071 hasRelatedWork W2000554875 @default.
• W2068750071 hasRelatedWork W2011904545 @default.
• W2068750071 hasRelatedWork W2128331079 @default.
• W2068750071 hasRelatedWork W2165511048 @default.
• W2068750071 hasRelatedWork W2199584405 @default.
• W2068750071 hasRelatedWork W2406552906 @default.
• W2068750071 hasRelatedWork W4246282865 @default.
• W2068750071 hasVolume "286" @default.
• W2068750071 isParatext "false" @default.
• W2068750071 isRetracted "false" @default.

• next