FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068752105> ?p ?o ?g. }

• W2068752105 abstract "ABSTRACT Adult rats were made unilaterally cryptorchid (UCD) and 6–7 weeks later Leydig cells were isolated from the scrotal and abdominal testes and their capacity to secrete testosterone in vitro was compared. Basal testosterone production by Leydig cells from the abdominal testes of UCD rats was lowered, compared with cells from the contralateral scrotal testes, whilst their responsiveness to both human chorionic gonadotrophin and an LH releasing hormone agonist was enhanced two- to threefold ( P < 0·001) compared both with cells from the contralateral scrotal testes and with cells isolated from untreated rats of the same age. In the UCD rats, concentrations of testosterone in testicular interstitial fluid (IF) were reduced ( P < 0·001) by 70–90% in abdominal, compared with scrotal, testes. A similar reduction was evident in the levels of testosterone in spermatic venous blood, and both this decrease and that in IF levels of testosterone varied according to the degree of testicular involution. The ontogeny of the above changes was investigated. After induction of unilateral cryptorchidism, the weight of the abdominal compared with the scrotal testis declined slowly, such that by day 5 there was only a 25% reduction in weight compared with a 70% reduction by day 40. In contrast, the levels of testosterone in IF from abdominal testes declined rapidly, such that by day 5 an 80% reduction was attained, compared with scrotal testes, with little further change by day 40. Hormone-stimulated testosterone production by Leydig cells isolated from the abdominal testes was unchanged or marginally reduced over the first 3 days compared with cells from the scrotal testes, but by day 5 there was a significant increase in responsiveness; this increase was of smaller magnitude than that evident at day 40. These results suggest a possible association between the fall in intratesticular levels of testosterone induced by unilateral cryptorchidism and the Leydig cell hypertrophy and hyper-responsiveness that occurs in the same testes. The implications with respect to altered Sertoli–Leydig cell interaction are discussed. J. Endocr. (1984) 102 , 319–327" @default.
• W2068752105 created "2016-06-24" @default.
• W2068752105 creator A5008660502 @default.
• W2068752105 creator A5041411967 @default.
• W2068752105 creator A5065244211 @default.
• W2068752105 date "1984-09-01" @default.
• W2068752105 modified "2023-09-25" @default.
• W2068752105 title "Increase in Leydig cell responsiveness in the unilaterally cryptorchid rat testis and its relationship to the intratesticular levels of testosterone" @default.
• W2068752105 doi "https://doi.org/10.1677/joe.0.1020319" @default.
• W2068752105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6148374" @default.
• W2068752105 hasPublicationYear "1984" @default.
• W2068752105 type Work @default.
• W2068752105 sameAs 2068752105 @default.
• W2068752105 citedByCount "31" @default.
• W2068752105 countsByYear W20687521052012 @default.
• W2068752105 countsByYear W20687521052014 @default.
• W2068752105 crossrefType "journal-article" @default.
• W2068752105 hasAuthorship W2068752105A5008660502 @default.
• W2068752105 hasAuthorship W2068752105A5041411967 @default.
• W2068752105 hasAuthorship W2068752105A5065244211 @default.
• W2068752105 hasConcept C126322002 @default.
• W2068752105 hasConcept C134018914 @default.
• W2068752105 hasConcept C2777736315 @default.
• W2068752105 hasConcept C2778024521 @default.
• W2068752105 hasConcept C2778575703 @default.
• W2068752105 hasConcept C2779066085 @default.
• W2068752105 hasConcept C2779279991 @default.
• W2068752105 hasConcept C2779306644 @default.
• W2068752105 hasConcept C71315377 @default.
• W2068752105 hasConcept C71924100 @default.
• W2068752105 hasConcept C86803240 @default.
• W2068752105 hasConceptScore W2068752105C126322002 @default.
• W2068752105 hasConceptScore W2068752105C134018914 @default.
• W2068752105 hasConceptScore W2068752105C2777736315 @default.
• W2068752105 hasConceptScore W2068752105C2778024521 @default.
• W2068752105 hasConceptScore W2068752105C2778575703 @default.
• W2068752105 hasConceptScore W2068752105C2779066085 @default.
• W2068752105 hasConceptScore W2068752105C2779279991 @default.
• W2068752105 hasConceptScore W2068752105C2779306644 @default.
• W2068752105 hasConceptScore W2068752105C71315377 @default.
• W2068752105 hasConceptScore W2068752105C71924100 @default.
• W2068752105 hasConceptScore W2068752105C86803240 @default.
• W2068752105 hasLocation W20687521051 @default.
• W2068752105 hasLocation W20687521052 @default.
• W2068752105 hasOpenAccess W2068752105 @default.
• W2068752105 hasPrimaryLocation W20687521051 @default.
• W2068752105 hasRelatedWork W130698877 @default.
• W2068752105 hasRelatedWork W1985573982 @default.
• W2068752105 hasRelatedWork W1993764413 @default.
• W2068752105 hasRelatedWork W2003997084 @default.
• W2068752105 hasRelatedWork W2014027373 @default.
• W2068752105 hasRelatedWork W2030888346 @default.
• W2068752105 hasRelatedWork W2040706140 @default.
• W2068752105 hasRelatedWork W2081077785 @default.
• W2068752105 hasRelatedWork W2087168955 @default.
• W2068752105 hasRelatedWork W2153510880 @default.
• W2068752105 isParatext "false" @default.
• W2068752105 isRetracted "false" @default.
• W2068752105 magId "2068752105" @default.
• W2068752105 workType "article" @default.