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- W2068752622 abstract "Carotid intima-media thickening (CIMT) is a marker of both arteriosclerotic and atherosclerotic risks. Technological advances have semiautomated CIMT image acquisition and quantification. Studies comparing manual and automated methods have yielded conflicting results possibly due to plaque inclusion in measurements. Low atherosclerotic risk subjects<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mo stretchy=false>(</mml:mo><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>126</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>were recruited to minimise the effect of focal atherosclerotic lesions on CIMT variability. CIMT was assessed by high-resolution B-mode ultrasound (Philips HDX7E, Phillips, UK) images of the common carotid artery using both manual and semiautomated methods (QLAB, Phillips, UK). Intraclass correlation coefficient (ICC) and the mean differences of paired measurements (Bland-Altman method) were used to compare both methodologies. The ICC of manual (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mn>0.547</mml:mn><mml:mo>±</mml:mo><mml:mn>0.095</mml:mn></mml:math> mm) and automated (0.524 ± 0.068 mm) methods was<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>R</mml:mi><mml:mo>=</mml:mo><mml:mn>0.74</mml:mn></mml:math>and an absolute mean bias ± SD of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mn>0.023</mml:mn><mml:mo>±</mml:mo><mml:mn>0.052</mml:mn></mml:math> mm was observed. Interobserver and intraobserver ICC were greater for automated (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>R</mml:mi><mml:mo>=</mml:mo><mml:mn>0.94</mml:mn></mml:math>and 0.99) compared to manual (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>R</mml:mi><mml:mo>=</mml:mo><mml:mn>0.72</mml:mn></mml:math>and 0.88) methods. Although not considered to be clinically significant, manual measurements yielded higher values compared to automated measurements. Automated measurements were more reproducible and showed lower interobserver variation compared to manual measurements. These results offer important considerations for large epidemiological studies." @default.
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- W2068752622 date "2014-01-01" @default.
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- W2068752622 title "Comparison of Semi-Automated and Manual Measurements of Carotid Intima-Media Thickening" @default.
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- W2068752622 doi "https://doi.org/10.1155/2014/531389" @default.
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