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- W2068753838 abstract "Activities of nine lysosomal enzymes and pH-dependent isozyme patterns of α-mannosidase were examined in the skeletal muscle of patients with neuromuscular diseases, and the ratios of these enzyme activities in leukocytes to those in myocytes (L/M ratio) were determined. The activities of enzymes with a high L/M ratio were markedly increased in the muscles of patients with Duchenne muscular dystrophy (DMD), myotonic dystrophy (MyD), or polymyositis (PM). In contrast, those which showed a low L/M ratio were increased in the muscles of amyotrophic lateral sclerosis (ALS) and disuse muscle atrophy (DUA). The isozyme pattern of α-mannosidase in DMD muscle resembled that in leukocytes, while those in ALS and DUA muscle resembled that in normal muscle. These results may suggest that the increased activity of lysosomal enzymes in the muscles of patients with DMD, MyD, or PM is due primarily to infiltrating leukocytes, while that in patients with ALS or DUA is due to intramyofiber lysosomes. © 1995 John Wiley & Sons, Inc." @default.
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- W2068753838 date "1995-09-01" @default.
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- W2068753838 title "Lysosomal enzyme activities in skeletal muscle of patients with neuromuscular diseases" @default.
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- W2068753838 doi "https://doi.org/10.1002/mus.880180913" @default.
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