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• W2068756005 abstract "With the large number of antithrombotic therapies available and under investigation for the treatment of non–ST-segment elevation acute coronary syndromes (NSTE ACS), practice guidelines now stress the importance of selecting an antithrombotic strategy according to the efficacy and safety profiles of the chosen agent. Contemporary trials have incorporated bleeding along with ischemic end points into a composite end point commonly referred to as net clinical benefit, which allows for simultaneous evaluation of the differences between benefit and harm for an investigational antithrombotic therapy. However, incorporating major bleeding into a composite end point that includes ischemic events is not warranted and is associated with many pitfalls. In this article, we discuss the validity of combining efficacy and safety end points to form a net clinical benefit composite end point with the traditional time-to-event analysis for trials evaluating antithrombotic therapies for NSTE ACS. We describe alternative statistical approaches for concurrent assessment of the safety and efficacy of antithrombotic therapies used to treat patients with NSTE ACS." @default.
• W2068756005 created "2016-06-24" @default.
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• W2068756005 date "2013-05-01" @default.
• W2068756005 modified "2023-10-14" @default.
• W2068756005 title "Incorporation of bleeding as an element of the composite end point in clinical trials of antithrombotic therapies in patients with non–ST-segment elevation acute coronary syndrome: Validity, pitfalls, and future approaches" @default.
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• W2068756005 doi "https://doi.org/10.1016/j.ahj.2012.11.012" @default.
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• W2068756005 hasPublicationYear "2013" @default.
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