FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068757064> ?p ?o ?g. }

• W2068757064 endingPage "2020" @default.
• W2068757064 startingPage "2011" @default.
• W2068757064 abstract "The rhizome of Curcuma longa (CL) has been commonly used in Asia as a potential candidate for the treatment of different diseases, including inflammatory disorders and cancers. The present study evaluated the anti-proliferative activities of the isolated compounds (three curcuminoids and two turmerones) from CL, using human cancer cell lines HepG2, MCF-7 and MDA-MB-231. The immunomodulatory activities of turmerones (alpha and aromatic) isolated from CL were also examined using human peripheral blood mononuclear cells (PBMC). Our results showed that the curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) and alpha-turmerone significantly inhibited proliferation of cancer cells in dose-dependent manner. The IC(50) values of these compounds in cancer cells ranged from 11.0 to 41.8 microg/ml. alpha-Turmerone induced MDA-MB-231 cells to undergo apoptosis, which was confirmed by annexin-V and propidium iodide staining, and DNA fragmentation assay. The caspase cascade was activated as shown by a significant decrease of procaspases-3, -8 and -9 in alpha-turmerone treated cells. Both alpha-turmerone and aromatic-turmerone showed stimulatory effects on PBMC proliferation and cytokine production. The anti-proliferative effect of alpha-turmerone and immunomodulatory activities of ar-turmerone was shown for the first time. The findings revealed the potential use of CL crude extract (containing curcuminoids and volatile oil including turmerones) as chemopreventive agent." @default.
• W2068757064 created "2016-06-24" @default.
• W2068757064 creator A5002582581 @default.
• W2068757064 creator A5009913628 @default.
• W2068757064 creator A5015038302 @default.
• W2068757064 creator A5041465938 @default.
• W2068757064 creator A5045325690 @default.
• W2068757064 creator A5072141108 @default.
• W2068757064 creator A5089501424 @default.
• W2068757064 date "2010-08-01" @default.
• W2068757064 modified "2023-10-13" @default.
• W2068757064 title "Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa" @default.
• W2068757064 cites W192197890 @default.
• W2068757064 cites W1929698897 @default.
• W2068757064 cites W1965743421 @default.
• W2068757064 cites W1969017801 @default.
• W2068757064 cites W1974834318 @default.
• W2068757064 cites W1978288650 @default.
• W2068757064 cites W1979585294 @default.
• W2068757064 cites W1986785675 @default.
• W2068757064 cites W1990351531 @default.
• W2068757064 cites W1990668127 @default.
• W2068757064 cites W1995997034 @default.
• W2068757064 cites W2007633892 @default.
• W2068757064 cites W2017075943 @default.
• W2068757064 cites W2021931700 @default.
• W2068757064 cites W2029136090 @default.
• W2068757064 cites W2040387495 @default.
• W2068757064 cites W2041367964 @default.
• W2068757064 cites W2045324074 @default.
• W2068757064 cites W2046767433 @default.
• W2068757064 cites W2047895520 @default.
• W2068757064 cites W2048639599 @default.
• W2068757064 cites W2053580616 @default.
• W2068757064 cites W2061317234 @default.
• W2068757064 cites W2071509119 @default.
• W2068757064 cites W2076772458 @default.
• W2068757064 cites W2080573554 @default.
• W2068757064 cites W2081401587 @default.
• W2068757064 cites W2083911989 @default.
• W2068757064 cites W2096685256 @default.
• W2068757064 cites W2121411068 @default.
• W2068757064 cites W2124197001 @default.
• W2068757064 cites W2139433964 @default.
• W2068757064 cites W2151501496 @default.
• W2068757064 cites W2157428697 @default.
• W2068757064 cites W2166233009 @default.
• W2068757064 cites W2170804837 @default.
• W2068757064 cites W2187456576 @default.
• W2068757064 cites W2318388129 @default.
• W2068757064 doi "https://doi.org/10.1016/j.fct.2010.04.039" @default.
• W2068757064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2910176" @default.
• W2068757064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20438793" @default.
• W2068757064 hasPublicationYear "2010" @default.
• W2068757064 type Work @default.
• W2068757064 sameAs 2068757064 @default.
• W2068757064 citedByCount "107" @default.
• W2068757064 countsByYear W20687570642012 @default.
• W2068757064 countsByYear W20687570642013 @default.
• W2068757064 countsByYear W20687570642014 @default.
• W2068757064 countsByYear W20687570642015 @default.
• W2068757064 countsByYear W20687570642016 @default.
• W2068757064 countsByYear W20687570642017 @default.
• W2068757064 countsByYear W20687570642018 @default.
• W2068757064 countsByYear W20687570642019 @default.
• W2068757064 countsByYear W20687570642020 @default.
• W2068757064 countsByYear W20687570642021 @default.
• W2068757064 countsByYear W20687570642022 @default.
• W2068757064 countsByYear W20687570642023 @default.
• W2068757064 crossrefType "journal-article" @default.
• W2068757064 hasAuthorship W2068757064A5002582581 @default.
• W2068757064 hasAuthorship W2068757064A5009913628 @default.
• W2068757064 hasAuthorship W2068757064A5015038302 @default.
• W2068757064 hasAuthorship W2068757064A5041465938 @default.
• W2068757064 hasAuthorship W2068757064A5045325690 @default.
• W2068757064 hasAuthorship W2068757064A5072141108 @default.
• W2068757064 hasAuthorship W2068757064A5089501424 @default.
• W2068757064 hasBestOaLocation W20687570642 @default.
• W2068757064 hasConcept C137061746 @default.
• W2068757064 hasConcept C185592680 @default.
• W2068757064 hasConcept C190283241 @default.
• W2068757064 hasConcept C202751555 @default.
• W2068757064 hasConcept C2775934118 @default.
• W2068757064 hasConcept C2777230291 @default.
• W2068757064 hasConcept C2778250585 @default.
• W2068757064 hasConcept C31573885 @default.
• W2068757064 hasConcept C43759708 @default.
• W2068757064 hasConcept C55493867 @default.
• W2068757064 hasConcept C556039675 @default.
• W2068757064 hasConcept C71924100 @default.
• W2068757064 hasConcept C86803240 @default.
• W2068757064 hasConcept C88634738 @default.
• W2068757064 hasConcept C98274493 @default.
• W2068757064 hasConceptScore W2068757064C137061746 @default.
• W2068757064 hasConceptScore W2068757064C185592680 @default.
• W2068757064 hasConceptScore W2068757064C190283241 @default.
• W2068757064 hasConceptScore W2068757064C202751555 @default.
• W2068757064 hasConceptScore W2068757064C2775934118 @default.

• next