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- W2068757584 endingPage "380" @default.
- W2068757584 startingPage "368" @default.
- W2068757584 abstract "One of the hallmarks of alcoholism is continued excessive consumption of alcohol-containing beverages despite the negative consequences of such behavior. The neurocircuitry regulating alcohol consumption is not well understood. Recent studies have shown that the neuropeptide urocortin 1 (Ucn1), a member of the corticotropin-releasing factor (CRF) family of peptides, could be an important player in the regulation of alcohol consumption. This evidence is accumulated along three directions of research: (1) Ucn 1-containing neurons are extremely sensitive to alcohol; (2) the Ucn1 neurocircuit may contribute to the genetic predisposition to high alcohol intake in mice and rats; (3) manipulation of the Ucn1 system alters alcohol consumption and sensitivity. This paper reviews the current knowledge of the Ucn1 neurocircuit and the evidence for its involvement in alcohol-related behaviors, and proposes a mechanism for its involvement in the regulation of alcohol consumption." @default.
- W2068757584 created "2016-06-24" @default.
- W2068757584 creator A5003072259 @default.
- W2068757584 creator A5055957325 @default.
- W2068757584 date "2006-09-01" @default.
- W2068757584 modified "2023-09-27" @default.
- W2068757584 title "The urocortin 1 neurocircuit: Ethanol-sensitivity and potential involvement in alcohol consumption" @default.
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