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- W2068757628 abstract "Methotrexate (MTX) is one of the most widely used therapies in rheumatoid arthritis (RA) due to its anti-inflammatory and potential bone protection effect. Bone biology is governed by the RANKL/RANK/OPG system that determines the balance between bone formation by osteoblasts and bone resorption by osteoclasts. We investigated the effects of MTX on the RANKL/RANK/OPG system in vivo and in vitro.16 patients with newly diagnosed RA (mean disease duration 1 week) were started …" @default.
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- W2068757628 date "2010-03-01" @default.
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- W2068757628 title "Methothrexate directly inhibits RANKL expression and osteoclast formation in very early arthritis" @default.
- W2068757628 doi "https://doi.org/10.1136/ard.2010.129593t" @default.
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